Identity
HGNC
LOCATION
19q13.32
LOCUSID
ALIAS
GRF-1,GRLF1,P190-A,P190A,p190ARhoGAP,p190RhoGAP
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2909
MIM: 605277
HGNC: 4591
Ensembl: ENSG00000160007
Variants:
dbSNP: 2909
ClinVar: 2909
TCGA: ENSG00000160007
COSMIC: ARHGAP35
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000160007 | ENST00000404338 | Q9NRY4 |
| ENSG00000160007 | ENST00000614079 | Q9NRY4 |
| ENSG00000160007 | ENST00000672722 | Q9NRY4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36257976 | 2023 | Tumor-derived ARHGAP35 mutations enhance the Gα(13)-Rho signaling axis in human endometrial cancer. | 1 |
| 36450800 | 2023 | ARHGAP35 is a novel factor disrupted in human developmental eye phenotypes. | 3 |
| 36516886 | 2023 | Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain. | 1 |
| 37507023 | 2023 | Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1. | 2 |
| 36257976 | 2023 | Tumor-derived ARHGAP35 mutations enhance the Gα(13)-Rho signaling axis in human endometrial cancer. | 1 |
| 36450800 | 2023 | ARHGAP35 is a novel factor disrupted in human developmental eye phenotypes. | 3 |
| 36516886 | 2023 | Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain. | 1 |
| 37507023 | 2023 | Diverse p120RasGAP interactions with doubly phosphorylated partners EphB4, p190RhoGAP, and Dok1. | 2 |
| 35758029 | 2022 | Rho GTPase-activating protein 35 suppresses gastric cancer metastasis by regulating cytoskeleton reorganization and epithelial-to-mesenchymal transition. | 3 |
| 36178483 | 2022 | The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay. | 1 |
| 35758029 | 2022 | Rho GTPase-activating protein 35 suppresses gastric cancer metastasis by regulating cytoskeleton reorganization and epithelial-to-mesenchymal transition. | 3 |
| 36178483 | 2022 | The p190 RhoGAPs, ARHGAP35, and ARHGAP5 are implicated in GnRH neuronal development: Evidence from patients with idiopathic hypogonadotropic hypogonadism, zebrafish, and in vitro GAP activity assay. | 1 |
| 32457342 | 2020 | p190A inactivating mutations cause aberrant RhoA activation and promote malignant transformation via the Hippo-YAP pathway in endometrial cancer. | 9 |
| 32641858 | 2020 | p190A RhoGAP induces CDH1 expression and cooperates with E-cadherin to activate LATS kinases and suppress tumor cell growth. | 8 |
| 32663194 | 2020 | Polycystin-1 regulates ARHGAP35-dependent centrosomal RhoA activation and ROCK signaling. | 17 |
Citation
Dessen P
ARHGAP35 (Rho GTPase activating protein 35)
Atlas Genet Cytogenet Oncol Haematol. 2011-06-01
Online version: http://atlasgeneticsoncology.org/gene/52237/arhgap35-(rho-gtpase-activating-protein-35)
