IREB2 (iron responsive element binding protein 2)

2011-06-01  

Identity

HGNC
IREB2
LOCATION
15q25.1
LOCUSID
3658
ALIAS
ACO3,IRE-BP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3658
MIM: 147582
HGNC: 6115
Ensembl: ENSG00000136381

Variants:

dbSNP: 3658
ClinVar: 3658
TCGA: ENSG00000136381
COSMIC: IREB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000136381ENST00000258886P48200
ENSG00000136381ENST00000558525H0YL48
ENSG00000136381ENST00000558570H0YNL8
ENSG00000136381ENST00000559091H0YN46
ENSG00000136381ENST00000559215H0YMA8
ENSG00000136381ENST00000560440P48200
ENSG00000136381ENST00000560840H0YLE0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366002582023KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.2
366002582023KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.2
355996312022MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2.20
355996312022MiR-19a suppresses ferroptosis of colorectal cancer cells by targeting IREB2.20
319079962020Mdm2 is a target and mediator of IRP2 in cell growth control.9
321262072020FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.49
322769912020Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.6
328130082020IRP2-Hif1α/Hif2α signaling: a novel mechanism of metabolic switch from aerobic glycolysis to oxidative phosphorylation.0
319079962020Mdm2 is a target and mediator of IRP2 in cell growth control.9
321262072020FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.49
322769912020Iron Regulatory Protein 2 Exerts its Oncogenic Activities by Suppressing TAp63 Expression.6
328130082020IRP2-Hif1α/Hif2α signaling: a novel mechanism of metabolic switch from aerobic glycolysis to oxidative phosphorylation.0
310927042019Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism.8
313322902019Iron regulatory protein 2 is a suppressor of mutant p53 in tumorigenesis.8
310927042019Zinc induces iron uptake and DMT1 expression in Caco-2 cells via a PI3K/IRP2 dependent mechanism.8

Citation

Dessen P

IREB2 (iron responsive element binding protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52239/ireb2-(iron-responsive-element-binding-protein-2)