HNRNPL (heterogeneous nuclear ribonucleoprotein L)

2011-06-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
HNRPL,P/OKcl.14,hnRNP-L
FUSION GENES

Other Information

Locus ID:

NCBI: 3191
MIM: 603083
HGNC: 5045
Ensembl: ENSG00000104824

Variants:

dbSNP: 3191
ClinVar: 3191
TCGA: ENSG00000104824
COSMIC: HNRNPL

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104824ENST00000221419P14866
ENSG00000104824ENST00000388749B4DVF8
ENSG00000104824ENST00000600233M0R1W6
ENSG00000104824ENST00000600873P14866
ENSG00000104824ENST00000601449M0QXS5
ENSG00000104824ENST00000601813M0QYL7
ENSG00000104824ENST00000647557A0A3B3ITJ4

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
243713102014The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL.208
180733452008Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis.75
124473482003HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats.72
191246112009Auto- and cross-regulation of the hnRNP L proteins by alternative splicing.56
201224042010Context-dependent regulatory mechanism of the splicing factor hnRNP L.56
213439072011Repression of VEGFA by CA-rich element-binding microRNAs is modulated by hnRNP L.56
245260102014Crosslinking-immunoprecipitation (iCLIP) analysis reveals global regulatory roles of hnRNP L.42
193325502009Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.41
160247702005Binding of hnRNP L to the pre-mRNA processing enhancer of the herpes simplex virus thymidine kinase gene enhances both polyadenylation and nucleocytoplasmic export of intronless mRNAs.37
233949982013hnRNP L and hnRNP A1 induce extended U1 snRNA interactions with an exon to repress spliceosome assembly.36

Citation

Dessen P

HNRNPL (heterogeneous nuclear ribonucleoprotein L)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52244/hnrnpl-(heterogeneous-nuclear-ribonucleoprotein-l)