AKTIP (AKT interacting protein)

2011-06-01  

Identity

HGNC
AKTIP
LOCATION
16q12.2
LOCUSID
64400
ALIAS
FT1,FTS

Other Information

Locus ID:

NCBI: 64400
MIM: 608483
HGNC: 16710
Ensembl: ENSG00000166971

Variants:

dbSNP: 64400
ClinVar: 64400
TCGA: ENSG00000166971
COSMIC: AKTIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166971ENST00000300245Q9H8T0
ENSG00000166971ENST00000300245A0A024R6S6
ENSG00000166971ENST00000394657Q9H8T0
ENSG00000166971ENST00000394657A0A024R6T5
ENSG00000166971ENST00000563928H3BRV2
ENSG00000166971ENST00000564497H3BRT7
ENSG00000166971ENST00000565408H3BVH0
ENSG00000166971ENST00000568022H3BM79
ENSG00000166971ENST00000568596H3BNB8
ENSG00000166971ENST00000570004Q9H8T0
ENSG00000166971ENST00000570004A0A024R6T5
ENSG00000166971ENST00000570041H3BSX7

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360968082022Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.2
365167752022AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance.1
360968082022Combined alteration of lamin and nuclear morphology influences the localization of the tumor-associated factor AKTIP.2
365167752022AKTIP loss is enriched in ERα-positive breast cancer for tumorigenesis and confers endocrine resistance.1
344497662021AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.12
344497662021AKTIP interacts with ESCRT I and is needed for the recruitment of ESCRT III subunits to the midbody.12
273422162016Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity.6
275121402016The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.19
275358352016Silencing of fused toes homolog enhances cisplatin sensitivity in cervical cancer cells by inhibiting epidermal growth factor receptor-mediated repair of DNA damage.5
273422162016Lack of association between genetic polymorphism of FTO, AKT1 and AKTIP in childhood overweight and obesity.6
275121402016The telomeric protein AKTIP interacts with A- and B-type lamins and is involved in regulation of cellular senescence.19
275358352016Silencing of fused toes homolog enhances cisplatin sensitivity in cervical cancer cells by inhibiting epidermal growth factor receptor-mediated repair of DNA damage.5
251515762015FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells.8
261105282015AKTIP/Ft1, a New Shelterin-Interacting Factor Required for Telomere Maintenance.27
251515762015FTS is responsible for radiation-induced nuclear phosphorylation of EGFR and repair of DNA damage in cervical cancer cells.8

Citation

Dessen P

AKTIP (AKT interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52260/aktip-(akt-interacting-protein)