ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3)

2011-06-01  

Identity

HGNC
ARAP3
LOCATION
5q31.3
LOCUSID
64411
ALIAS
CENTD3,DRAG1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 64411
MIM: 606647
HGNC: 24097
Ensembl: ENSG00000120318

Variants:

dbSNP: 64411
ClinVar: 64411
TCGA: ENSG00000120318
COSMIC: ARAP3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120318ENST00000239440Q8WWN8
ENSG00000120318ENST00000504448Q05CH1
ENSG00000120318ENST00000508305G5E9Y3
ENSG00000120318ENST00000513878Q8WWN8
ENSG00000120318ENST00000626478G5E9Y3

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
366746452023Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3.0
366746452023Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3.0
273117132016Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3.7
273117132016Structural Basis for the Specific Recognition of RhoA by the Dual GTPase-activating Protein ARAP3.7
231808202013Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.10
232395782013Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights.6
231808202013Phosphoinositide 3-OH kinase regulates integrin-dependent processes in neutrophils by signaling through its effector ARAP3.10
232395782013Heterotypic Sam-Sam association between Odin-Sam1 and Arap3-Sam: binding affinity and structural insights.6
227504192012Identification and structural basis for a novel interaction between Vav2 and Arap3.5
227504192012Identification and structural basis for a novel interaction between Vav2 and Arap3.5
210764692011ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion.19
210764692011ARAP3 inhibits peritoneal dissemination of scirrhous gastric carcinoma cells by regulating cell adhesion and invasion.19
197860922010ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences.9
197860922010ARAP3 binding to phosphatidylinositol-(3,4,5)-trisphosphate depends on N-terminal tandem PH domains and adjacent sequences.9
173140302007The PI3K effector Arap3 interacts with the PI(3,4,5)P3 phosphatase SHIP2 in a SAM domain-dependent manner.16

Citation

Dessen P

ARAP3 (ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-06-01

Online version: http://atlasgeneticsoncology.org/gene/52262/arap3-(arfgap-with-rhogap-domain-ankyrin-repeat-and-ph-domain-3)