SLCO2B1 (solute carrier organic anion transporter family member 2B1)

2011-07-01  

Identity

HGNC
SLCO2B1
LOCATION
11q13.4
LOCUSID
11309
ALIAS
OATP-B,OATP2B1,OATPB,SLC21A9
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11309
MIM: 604988
HGNC: 10962
Ensembl: ENSG00000137491

Variants:

dbSNP: 11309
ClinVar: 11309
TCGA: ENSG00000137491
COSMIC: SLCO2B1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137491ENST00000289575A0A024R5I4
ENSG00000137491ENST00000428359O94956
ENSG00000137491ENST00000454962O94956
ENSG00000137491ENST00000525650A0A0A0MTF1
ENSG00000137491ENST00000525845A0A1B0GX35
ENSG00000137491ENST00000526839H0YE11
ENSG00000137491ENST00000527180E9PI53
ENSG00000137491ENST00000530556A0A1B0GX35
ENSG00000137491ENST00000531713E9PN87
ENSG00000137491ENST00000532236E9PRW4
ENSG00000137491ENST00000534004A0A1B0GX35
ENSG00000137491ENST00000534186E9PIU9

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of vitamins, nucleosides, and related moleculesREACTOMER-HSA-425397
Transport of organic anionsREACTOMER-HSA-879518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA133950441hmg coa reductase inhibitorsChemicalPathwayassociated
PA134308647rosuvastatinChemicalPathwayassociated
PA443450AsthmaDiseaseClinicalAnnotationassociatedPKPD19151602, 23970434
PA448500atorvastatinChemicalPathwayassociated
PA449621fexofenadineChemicalClinicalAnnotationassociatedPK21280267
PA449688fluvastatinChemicalPathwayassociated
PA450272lovastatinChemicalPathwayassociated
PA450546montelukastChemicalClinicalAnnotationassociatedPKPD19151602, 23970434
PA450573nadololChemicalLiterature, MultilinkAnnotationnot associated24419562
PA451089pravastatinChemicalPathwayassociated
PA451363simvastatinChemicalLiterature, MultilinkAnnotation, Pathwayassociated24598718

References

Pubmed IDYearTitleCitations
378567812024SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.0
384234812024Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.0
384326242024The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.0
378567812024SLCO1B3 and SLCO2B1 genotypes, androgen deprivation therapy, and prostate cancer outcomes: a prospective cohort study and meta-analysis.0
384234812024Roles of breast cancer resistance protein and organic anion transporting polypeptide 2B1 in gastrointestinal toxicity induced by SN-38 under inflammatory conditions.0
384326242024The Effects of N-Glycosylation on the Expression and Transport Activity of OATP1A2 and OATP2B1.0
362538932023Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.0
362538932023Genetic Polymorphisms in SLCO2B1 and ABCC1 Conjointly Modulate Atorvastatin Intracellular Accumulation in HEK293 Recombinant Cell Lines.0
347629302022Association of genetic polymorphisms with local steroid metabolism in human benign breasts.2
347629302022Association of genetic polymorphisms with local steroid metabolism in human benign breasts.2
337237952021Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.6
346283572021Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).3
337237952021Uptake Pathway of Apple-derived Nanoparticle by Intestinal Cells to Deliver its Cargo.6
346283572021Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1).3
318492832020Germline variants and response to systemic therapy in advanced prostate cancer.1

Citation

Dessen P

SLCO2B1 (solute carrier organic anion transporter family member 2B1)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52268/slco2b1-(solute-carrier-organic-anion-transporter-family-member-2b1)