Identity
HGNC
LOCATION
12q13.13
LOCUSID
ALIAS
CK-4,CK4,CYK4,K4,WSN1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3851
MIM: 123940
HGNC: 6441
Ensembl: ENSG00000170477
Variants:
dbSNP: 3851
ClinVar: 3851
TCGA: ENSG00000170477
COSMIC: KRT4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000170477 | ENST00000548097 | F8VX05 |
| ENSG00000170477 | ENST00000551956 | P19013 |
| ENSG00000170477 | ENST00000552668 | F8VZR6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36811004 | 2023 | Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. | 4 |
| 36811004 | 2023 | Splice site m(6)A methylation prevents binding of DGCR8 to suppress KRT4 pre-mRNA splicing in oral squamous cell carcinoma. | 4 |
| 35707935 | 2022 | Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer. | 0 |
| 36553451 | 2022 | White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report. | 1 |
| 35707935 | 2022 | Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer. | 0 |
| 36553451 | 2022 | White Sponge Nevus Caused by Keratin 4 Gene Mutation: A Case Report. | 1 |
| 32124945 | 2020 | CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. | 6 |
| 32124945 | 2020 | CD24 and CK4 are upregulated by SIM2, and are predictive biomarkers for chemoradiotherapy and surgery in esophageal cancer. | 6 |
| 29476668 | 2018 | Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus. | 4 |
| 29738605 | 2018 | Keratin 4 regulates the development of human white sponge nevus. | 4 |
| 29476668 | 2018 | Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus. | 4 |
| 29738605 | 2018 | Keratin 4 regulates the development of human white sponge nevus. | 4 |
| 25603146 | 2015 | Structure of KRT4 binding domain of Srr-1 from Streptococcus agalactiae reveals a novel β-sheet complementation. | 4 |
| 25603146 | 2015 | Structure of KRT4 binding domain of Srr-1 from Streptococcus agalactiae reveals a novel β-sheet complementation. | 4 |
| 23182699 | 2013 | Mutation of keratin 4 gene causing white sponge nevus in a Japanese family. | 5 |
Citation
Dessen P
KRT4 (keratin 4)
Atlas Genet Cytogenet Oncol Haematol. 2011-07-01
Online version: http://atlasgeneticsoncology.org/gene/52270
