RAD51B (RAD51 paralog B)

2011-07-01  

Identity

HGNC
RAD51B
LOCATION
14q24.1
LOCUSID
5890
ALIAS
R51H2,RAD51L1,REC2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5890
MIM: 602948
HGNC: 9822
Ensembl: ENSG00000182185

Variants:

dbSNP: 5890
ClinVar: 5890
TCGA: ENSG00000182185
COSMIC: RAD51B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182185ENST00000390683A0A0A0MS18
ENSG00000182185ENST00000471583O15315
ENSG00000182185ENST00000479335F8WAY6
ENSG00000182185ENST00000485181C9J5S9
ENSG00000182185ENST00000487270O15315
ENSG00000182185ENST00000487861C9JYJ0
ENSG00000182185ENST00000488612O15315
ENSG00000182185ENST00000553334G3V4W9
ENSG00000182185ENST00000554575H0YJI5

Expression (GTEx)

0
1
2
3
4
5
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Homologous recombinationKEGGko03440
Homologous recombinationKEGGhsa03440
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231
DNA RepairREACTOMER-HSA-73894
DNA Double-Strand Break RepairREACTOMER-HSA-5693532
Homology Directed RepairREACTOMER-HSA-5693538
HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)REACTOMER-HSA-5693567
HDR through Homologous Recombination (HRR)REACTOMER-HSA-5685942
Homologous DNA Pairing and Strand ExchangeREACTOMER-HSA-5693579
Presynaptic phase of homologous DNA pairing and strand exchangeREACTOMER-HSA-5693616
Resolution of D-Loop StructuresREACTOMER-HSA-5693537
Resolution of D-loop Structures through Holliday Junction IntermediatesREACTOMER-HSA-5693568
Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)REACTOMER-HSA-5693554

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374667652024Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases.0
381418292024Sarcomas With RAD51B Fusions Are Associated With a Heterogeneous Phenotype.0
374667652024Uterine leiomyoma with RAD51B::NUDT3 fusion: a report of 2 cases.0
381418292024Sarcomas With RAD51B Fusions Are Associated With a Heterogeneous Phenotype.0
373445872023Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.10
373445892023Structural insights into BCDX2 complex function in homologous recombination.7
373445872023Structure and function of the RAD51B-RAD51C-RAD51D-XRCC2 tumour suppressor.10
373445892023Structural insights into BCDX2 complex function in homologous recombination.7
357379132022RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma.1
357379132022RAD51B Harbors Germline Mutations Associated With Pancreatic Ductal Adenocarcinoma.1
336228742021TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene Polymorphisms and Associations With Pituitary Adenoma.1
340609912021Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration.5
336228742021TBX15 rs98422, DNM3 rs1011731, RAD51B rs8017304, and rs2588809 Gene Polymorphisms and Associations With Pituitary Adenoma.1
340609912021Serum Levels of ARMS2, COL8A1, RAD51B, and VEGF and their Correlations in Age-related Macular Degeneration.5
326696012020Sequential role of RAD51 paralog complexes in replication fork remodeling and restart.43

Citation

Dessen P

RAD51B (RAD51 paralog B)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52276