CHSY3 (chondroitin sulfate synthase 3)

2011-08-01  

Identity

HGNC
CHSY3
LOCATION
5q23.3
LOCUSID
337876
ALIAS
CHSY2,CSS3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 337876
MIM: 609963
HGNC: 24293
Ensembl: ENSG00000198108

Variants:

dbSNP: 337876
ClinVar: 337876
TCGA: ENSG00000198108
COSMIC: CHSY3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198108ENST00000305031Q70JA7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGko00532
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfateKEGGhsa00532
Metabolic pathwaysKEGGhsa01100
Glycosaminoglycan biosynthesis, chondroitin sulfate backboneKEGGhsa_M00058
Glycosaminoglycan biosynthesis, chondroitin sulfate backboneKEGGM00058
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Chondroitin sulfate/dermatan sulfate metabolismREACTOMER-HSA-1793185
Chondroitin sulfate biosynthesisREACTOMER-HSA-2022870

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
388125062024The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer.0
388125062024The prognostic implications and tumor-promoting functions of CHSY3 in gastric cancer.0
374610412023CHSY3 promotes proliferation and migration in gastric cancer and is associated with immune infiltration.5
374610412023CHSY3 promotes proliferation and migration in gastric cancer and is associated with immune infiltration.5
333907892021Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells.2
333907892021Reduction of pl-CSA through ChSy-2 knockout inhibits tumorigenesis and metastasis of choriocarcinoma in JEG3 cells.2
330895282020Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.6
330895282020Chondroitin synthase-3 regulates nucleus pulposus degeneration through actin-induced YAP signaling.6
214685782011Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.19
214685782011Chondroitin synthases I, II, III and chondroitin sulfate glucuronyltransferase expression in colorectal cancer.19
172539602007Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.44
172539602007Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor.44
129076872003Chondroitin sulfate synthase-3. Molecular cloning and characterization.22
129076872003Chondroitin sulfate synthase-3. Molecular cloning and characterization.22

Citation

Dessen P

CHSY3 (chondroitin sulfate synthase 3)

Atlas Genet Cytogenet Oncol Haematol. 2011-08-01

Online version: http://atlasgeneticsoncology.org/gene/52358/chsy3-(chondroitin-sulfate-synthase-3)