Identity
HGNC
LOCATION
1p12
LOCUSID
ALIAS
3-PGDH,3PGDH,HEL-S-113,NLS,NLS1,PDG,PGAD,PGD,PGDH,PHGDHD,SERA
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 26227
MIM: 606879
HGNC: 8923
Ensembl: ENSG00000092621
Variants:
dbSNP: 26227
ClinVar: 26227
TCGA: ENSG00000092621
COSMIC: PHGDH
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37249813 | 2024 | KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner. | 2 |
| 37650587 | 2024 | Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels. | 2 |
| 37991454 | 2024 | Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling. | 1 |
| 38383964 | 2024 | PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer. | 0 |
| 38654205 | 2024 | CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis. | 0 |
| 37249813 | 2024 | KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner. | 2 |
| 37650587 | 2024 | Biochemical and cellular studies of three human 3-phosphoglycerate dehydrogenase variants responsible for pathological reduced L-serine levels. | 2 |
| 37991454 | 2024 | Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling. | 1 |
| 38383964 | 2024 | PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer. | 0 |
| 38654205 | 2024 | CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis. | 0 |
| 36803157 | 2023 | Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma. | 1 |
| 36823188 | 2023 | PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma. | 14 |
| 36925195 | 2023 | The Role of ESRP1 in the Regulation of PHGDH in Estrogen Receptor-Positive Breast Cancer. | 1 |
| 37192160 | 2023 | PHGDH preserves one-carbon cycle to confer metabolic plasticity in chemoresistant gastric cancer during nutrient stress. | 7 |
| 36803157 | 2023 | Comprehensive analysis of PHGDH for predicting prognosis and immunotherapy response in patients with endometrial carcinoma. | 1 |
Citation
Dessen P
PHGDH (phosphoglycerate dehydrogenase)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/52399/phgdh-(phosphoglycerate-dehydrogenase)
