CLTA (clathrin light chain A)

2011-10-01  

Identity

HGNC
LOCATION
9p13.3
LOCUSID
ALIAS
LCA
FUSION GENES

Other Information

Locus ID:

NCBI: 1211
MIM: 118960
HGNC: 2090
Ensembl: ENSG00000122705

Variants:

dbSNP: 1211
ClinVar: 1211
TCGA: ENSG00000122705
COSMIC: CLTA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122705ENST00000242285P09496
ENSG00000122705ENST00000345519P09496
ENSG00000122705ENST00000396603P09496
ENSG00000122705ENST00000433436P09496
ENSG00000122705ENST00000464497F8WF69
ENSG00000122705ENST00000466396C9J8P9
ENSG00000122705ENST00000470744P09496
ENSG00000122705ENST00000493185S4R3F6
ENSG00000122705ENST00000538225P09496
ENSG00000122705ENST00000540080P09496

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Huntington's diseaseKEGGko05016
Huntington's diseaseKEGGhsa05016
LysosomeKEGGko04142
LysosomeKEGGhsa04142
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Bacterial invasion of epithelial cellsKEGGko05100
Bacterial invasion of epithelial cellsKEGGhsa05100
Endocrine and other factor-regulated calcium reabsorptionKEGGko04961
Endocrine and other factor-regulated calcium reabsorptionKEGGhsa04961
Synaptic vesicle cycleKEGGko04721
Synaptic vesicle cycleKEGGhsa04721
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Entry of Influenza Virion into Host Cell via EndocytosisREACTOMER-HSA-168275
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
MHC class II antigen presentationREACTOMER-HSA-2132295
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Retrograde neurotrophin signallingREACTOMER-HSA-177504
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
WNT5A-dependent internalization of FZD4REACTOMER-HSA-5099900
WNT5A-dependent internalization of FZD2, FZD5 and ROR2REACTOMER-HSA-5140745
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
trans-Golgi Network Vesicle BuddingREACTOMER-HSA-199992
Clathrin derived vesicle buddingREACTOMER-HSA-421837
Golgi Associated Vesicle BiogenesisREACTOMER-HSA-432722
Lysosome Vesicle BiogenesisREACTOMER-HSA-432720
Gap junction trafficking and regulationREACTOMER-HSA-157858
Gap junction traffickingREACTOMER-HSA-190828
Gap junction degradationREACTOMER-HSA-190873
Formation of annular gap junctionsREACTOMER-HSA-196025
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
LDL-mediated lipid transportREACTOMER-HSA-171052
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760
Recycling pathway of L1REACTOMER-HSA-437239
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665
VLDL interactionsREACTOMER-HSA-8855121
VLDLR internalisation and degradationREACTOMER-HSA-8866427
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126922382003Human rhinovirus type 2 is internalized by clathrin-mediated endocytosis.39
181653182008Clathrin light chains function in mannose phosphate receptor trafficking via regulation of actin assembly.28
216112032011IGF1R signaling in Ewing sarcoma is shaped by clathrin-/caveolin-dependent endocytosis.12
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
211521032010The mitotic arrest deficient protein MAD2B interacts with the clathrin light chain A during mitosis.11
161389052005Differential control of clathrin subunit dynamics measured with EW-FRAP microscopy.9
212034292010Ligand-induced tyrosine phosphorylation of cysteinyl leukotriene receptor 1 triggers internalization and signaling in intestinal epithelial cells.7
269755822016Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3.2
234601202013Noradrenaline induces binding of Clathrin light chain A to α1-adrenoceptors in the human prostate.0

Citation

Dessen P

CLTA (clathrin light chain A)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52431/clta-(clathrin-light-chain-a)