Identity
HGNC
LOCATION
12p12.2
LOCUSID
ALIAS
CGI-PDE,CGI-PDE
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5139
MIM: 123805
HGNC: 8778
Ensembl: ENSG00000172572
Variants:
dbSNP: 5139
ClinVar: 5139
TCGA: ENSG00000172572
COSMIC: PDE3A
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000172572 | ENST00000359062 | Q14432 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444552 | Hypertension | Disease | ClinicalAnnotation | associated | PD | 31327267 | |
| PA445048 | Nausea | Disease | ClinicalAnnotation | associated | PD | ||
| PA446051 | Vomiting | Disease | ClinicalAnnotation | associated | PD | ||
| PA449899 | hydrochlorothiazide | Chemical | ClinicalAnnotation | associated | PD | 31327267 | |
| PA452618 | opioids | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38244313 | 2024 | ALDOA coordinates PDE3A through the β-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations. | 0 |
| 38244313 | 2024 | ALDOA coordinates PDE3A through the β-catenin/ID3 axis to stimulate cancer metastasis and M2 polarization in lung cancer with EGFR mutations. | 0 |
| 36876489 | 2023 | Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure. | 4 |
| 37035914 | 2023 | Mutations in Phosphodiesterase 3A (PDE3A) Cause Hypertension Without Cardiac Damage. | 4 |
| 37244472 | 2023 | Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage. | 0 |
| 36876489 | 2023 | Disruption of Phosphodiesterase 3A Binding to SERCA2 Increases SERCA2 Activity and Reduces Mortality in Mice With Chronic Heart Failure. | 4 |
| 37035914 | 2023 | Mutations in Phosphodiesterase 3A (PDE3A) Cause Hypertension Without Cardiac Damage. | 4 |
| 37244472 | 2023 | Mutant phosphodiesterase 3A protects the kidney from hypertension-induced damage. | 0 |
| 36259389 | 2022 | Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage. | 9 |
| 36259389 | 2022 | Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage. | 9 |
| 32949251 | 2021 | Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation. | 5 |
| 33249558 | 2021 | Identification and functional study of genetic polymorphisms in cyclic nucleotide phosphodiesterase 3A (PDE3A). | 1 |
| 34272366 | 2021 | Structure of PDE3A-SLFN12 complex reveals requirements for activation of SLFN12 RNase. | 24 |
| 32949251 | 2021 | Impact of phosphodiesterases PDE3 and PDE4 on 5-hydroxytryptamine receptor4-mediated increase of cAMP in human atrial fibrillation. | 5 |
| 33249558 | 2021 | Identification and functional study of genetic polymorphisms in cyclic nucleotide phosphodiesterase 3A (PDE3A). | 1 |
Citation
Dessen P
PDE3A (phosphodiesterase 3A)
Atlas Genet Cytogenet Oncol Haematol. 2011-10-01
Online version: http://atlasgeneticsoncology.org/gene/52435/pde3a-(phosphodiesterase-3a)
