CD3D (CD3d molecule)

2011-10-01  

Identity

HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
CD3-DELTA,IMD19,T3D
FUSION GENES

Other Information

Locus ID:

NCBI: 915
MIM: 186790
HGNC: 1673
Ensembl: ENSG00000167286

Variants:

dbSNP: 915
ClinVar: 915
TCGA: ENSG00000167286
COSMIC: CD3D

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167286ENST00000300692P04234
ENSG00000167286ENST00000300692B0YIY4
ENSG00000167286ENST00000392884P04234
ENSG00000167286ENST00000529594E9PMT5
ENSG00000167286ENST00000534687H0YE18

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Hematopoietic cell lineageKEGGko04640
T cell receptor signaling pathwayKEGGko04660
Primary immunodeficiencyKEGGko05340
Hematopoietic cell lineageKEGGhsa04640
T cell receptor signaling pathwayKEGGhsa04660
Primary immunodeficiencyKEGGhsa05340
Chagas disease (American trypanosomiasis)KEGGko05142
Chagas disease (American trypanosomiasis)KEGGhsa05142
MeaslesKEGGko05162
MeaslesKEGGhsa05162
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
TCR signalingREACTOMER-HSA-202403
Phosphorylation of CD3 and TCR zeta chainsREACTOMER-HSA-202427
Translocation of ZAP-70 to Immunological synapseREACTOMER-HSA-202430
Generation of second messenger moleculesREACTOMER-HSA-202433
Downstream TCR signalingREACTOMER-HSA-202424
Costimulation by the CD28 familyREACTOMER-HSA-388841
PD-1 signalingREACTOMER-HSA-389948
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Clathrin-mediated endocytosisREACTOMER-HSA-8856828
Cargo recognition for clathrin-mediated endocytosisREACTOMER-HSA-8856825
Th1 and Th2 cell differentiationKEGGko04658
Th1 and Th2 cell differentiationKEGGhsa04658
Th17 cell differentiationKEGGko04659
Th17 cell differentiationKEGGhsa04659

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
376510922023Hypomethylation of CD3D promoter induces immune cell infiltration and supports malignant phenotypes in uveal melanoma.2
376510922023Hypomethylation of CD3D promoter induces immune cell infiltration and supports malignant phenotypes in uveal melanoma.2
333504312021Comprehensive analysis reveals a prognostic and therapeutic biomarker CD3D in the breast carcinoma microenvironment.12
333504312021Comprehensive analysis reveals a prognostic and therapeutic biomarker CD3D in the breast carcinoma microenvironment.12
280754282017Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.11
280754282017Balanced secretion of anti-CEA × anti-CD3 diabody chains using the 2A self-cleaving peptide maximizes diabody assembly and tumor-specific cytotoxicity.11
274940912016CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia.3
274940912016CD3D and PRKCQ work together to discriminate between B-cell and T-cell acute lymphoblastic leukemia.3
261090642015Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.22
264376312015Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma.15
261090642015Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.22
264376312015Identification of a FOXP3(+)CD3(+)CD56(+) population with immunosuppressive function in cancer tissues of human hepatocellular carcinoma.15
242886972014The respiratory presentation of severe combined immunodeficiency in two Mennonite children at a tertiary centre highlighting the importance of recognizing this pediatric emergency.0
254224322014Molecular architecture of the αβ T cell receptor-CD3 complex.65
242886972014The respiratory presentation of severe combined immunodeficiency in two Mennonite children at a tertiary centre highlighting the importance of recognizing this pediatric emergency.0

Citation

Dessen P

CD3D (CD3d molecule)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52453/cd3d-(cd3d-molecule)