CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1)

2011-11-01  

Identity

HGNC
CAPZA1
LOCATION
1p13.2
LOCUSID
829
ALIAS
CAPPA1,CAPZ,CAZ1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 829
MIM: 601580
HGNC: 1488
Ensembl: ENSG00000116489

Variants:

dbSNP: 829
ClinVar: 829
TCGA: ENSG00000116489
COSMIC: CAPZA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116489ENST00000263168P52907
ENSG00000116489ENST00000263168A0A024R0E5

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Advanced glycosylation endproduct receptor signalingREACTOMER-HSA-879415
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366438632023Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.9
366438632023Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.9
345040782021A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.42
347968742021Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.7
345040782021A barbed end interference mechanism reveals how capping protein promotes nucleation in branched actin networks.42
347968742021Capping protein regulates endosomal trafficking by controlling F-actin density around endocytic vesicles and recruiting RAB5 effectors.7
301761572019CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.29
301761572019CAPZA1 determines the risk of gastric carcinogenesis by inhibiting Helicobacter pylori CagA-degraded autophagy.29
280930672017CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.32
280930672017CAPZA1 modulates EMT by regulating actin cytoskeleton remodelling in hepatocellular carcinoma.32
267644072016Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.11
267644072016Disease causing mutations in inverted formin 2 regulate its binding to G-actin, F-actin capping protein (CapZ α-1) and profilin 2.11
265660782015Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end.57
265660782015Single-molecule visualization of a formin-capping protein 'decision complex' at the actin filament barbed end.57
235459442013Prognostic value of CAPZA1 overexpression in gastric cancer.18

Citation

Dessen P

CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1)

Atlas Genet Cytogenet Oncol Haematol. 2011-11-01

Online version: http://atlasgeneticsoncology.org/gene/52471/capza1-(capping-actin-protein-of-muscle-z-line-subunit-alpha-1)