SLC25A27 (solute carrier family 25 member 27)

2011-10-01  

Identity

HGNC
LOCATION
6p12.3
LOCUSID
ALIAS
UCP4

Other Information

Locus ID:

NCBI: 9481
MIM: 613725
HGNC: 21065
Ensembl: ENSG00000153291

Variants:

dbSNP: 9481
ClinVar: 9481
TCGA: ENSG00000153291
COSMIC: SLC25A27

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153291ENST00000371347O95847
ENSG00000153291ENST00000411689O95847
ENSG00000153291ENST00000603486Q5VTS8
ENSG00000153291ENST00000604127S4R3J2
ENSG00000153291ENST00000604217S4R3J2
ENSG00000153291ENST00000604616S4R300

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
The citric acid (TCA) cycle and respiratory electron transportREACTOMER-HSA-1428517
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.REACTOMER-HSA-163200
Mitochondrial Uncoupling ProteinsREACTOMER-HSA-166187
The fatty acid cycling modelREACTOMER-HSA-167826
The proton buffering modelREACTOMER-HSA-167827

References

Pubmed IDYearTitleCitations
293155812018Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.18
304251862018Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia.7
293155812018Parkinson's disease-related DJ-1 modulates the expression of uncoupling protein 4 against oxidative stress.18
304251862018Uncoupling protein 4 (UCP4) gene variability in neurodegenerative disorders: further evidence of association in Frontotemporal dementia.7
269230232016The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.9
269344802016Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis.8
269230232016The Genetic Variability of UCP4 Affects the Individual Susceptibility to Late-Onset Alzheimer's Disease and Modifies the Disease's Risk in APOE-ɛ4 Carriers.9
269344802016Effects of UCP4 on the Proliferation and Apoptosis of Chondrocytes: Its Possible Involvement and Regulation in Osteoarthritis.8
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.0
232661872013The mitochondrial transporter family SLC25: identification, properties and physiopathology.0
224277952012Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.17
225245672012Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.31
225803002012UCP4 is a target effector of the NF-κB c-Rel prosurvival pathway against oxidative stress.16
224277952012Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial Complex II in neuroblastoma cells.17
225245672012Toward understanding the mechanism of ion transport activity of neuronal uncoupling proteins UCP2, UCP4, and UCP5.31

Citation

Dessen P

SLC25A27 (solute carrier family 25 member 27)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52475/slc25a27