PARP14 (poly(ADP-ribose) polymerase family member 14)

2011-10-01  

Identity

HGNC
PARP14
LOCATION
3q21.1
LOCUSID
54625
ALIAS
ARTD8,BAL2,PARP-14,pART8
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 54625
MIM: 610028
HGNC: 29232
Ensembl: ENSG00000173193

Variants:

dbSNP: 54625
ClinVar: 54625
TCGA: ENSG00000173193
COSMIC: PARP14

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173193ENST00000460683H7C5R8
ENSG00000173193ENST00000474629Q460N5
ENSG00000173193ENST00000494811H7C4Y3
ENSG00000173193ENST00000649945A0A3B3ITD5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376124992024PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.0
384671802024Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.1
386124132024PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.0
376124992024PARP14 correlates with GBM proliferation and poor prognosis by elevating expression of SAMD/SAMD9L.0
384671802024Targeting PARP14 with lomitapide suppresses drug resistance through the activation of DRP1-induced mitophagy in multiple myeloma.1
386124132024PARP14 Contributes to the Development of the Tumor-Associated Macrophage Phenotype.0
376509462023Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.0
376509462023Exploration of glycosyltransferases mutation status in cervical cancer reveals PARP14 as a potential prognostic marker.0
359143512022PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.1
359448792022PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1α expression.10
361073662022NMR study of human macroPARPs domains: (1)H, (15)N and (13)C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state.0
359143512022PARP14 regulates EP4 receptor expression in human colon cancer HCA-7 cells.1
359448792022PARP14 promotes the growth and glycolysis of acute myeloid leukemia cells by regulating HIF-1α expression.10
361073662022NMR study of human macroPARPs domains: (1)H, (15)N and (13)C resonance assignment of hPARP14 macro domain 2 in the free and the ADPr bound state.0
334679122021The potential association between PARP14 and SARS-CoV-2 infection (COVID-19).6

Citation

Dessen P

PARP14 (poly(ADP-ribose) polymerase family member 14)

Atlas Genet Cytogenet Oncol Haematol. 2011-10-01

Online version: http://atlasgeneticsoncology.org/gene/52482/parp14-(poly(adp-ribose)-polymerase-family-member-14)