Identity
HGNC
LOCATION
17q23.3
LOCUSID
ALIAS
AN11,HAN11,SWAN-1,WDR68
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10238
MIM: 605973
HGNC: 30915
Ensembl: ENSG00000136485
Variants:
dbSNP: 10238
ClinVar: 10238
TCGA: ENSG00000136485
COSMIC: DCAF7
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000136485 | ENST00000415273 | P61962 |
| ENSG00000136485 | ENST00000431926 | P61962 |
| ENSG00000136485 | ENST00000614556 | P61962 |
| ENSG00000136485 | ENST00000615512 | A0A087WWI6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36939378 | 2023 | MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. | 4 |
| 36939378 | 2023 | MEN1 Degradation Induced by Neddylation and the CUL4B-DCAF7 Axis Promotes Pancreatic Neuroendocrine Tumor Progression. | 4 |
| 31493872 | 2019 | DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair. | 4 |
| 31493872 | 2019 | DCAF7 is required for maintaining the cellular levels of ERCC1-XPF and nucleotide excision repair. | 4 |
| 30496304 | 2018 | DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B. | 10 |
| 30496304 | 2018 | DCAF7/WDR68 is required for normal levels of DYRK1A and DYRK1B. | 10 |
| 27307198 | 2016 | The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. | 29 |
| 27573245 | 2016 | Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex. | 14 |
| 27307198 | 2016 | The adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2. | 29 |
| 27573245 | 2016 | Human DNA Ligase I Interacts with and Is Targeted for Degradation by the DCAF7 Specificity Factor of the Cul4-DDB1 Ubiquitin Ligase Complex. | 14 |
| 25342745 | 2014 | The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation. | 24 |
| 25342745 | 2014 | The molecular chaperone TRiC/CCT binds to the Trp-Asp 40 (WD40) repeat protein WDR68 and promotes its folding, protein kinase DYRK1A binding, and nuclear accumulation. | 24 |
| 21777625 | 2011 | DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. | 33 |
| 21777625 | 2011 | DYRK1A binds to an evolutionarily conserved WD40-repeat protein WDR68 and induces its nuclear translocation. | 33 |
| 20940704 | 2010 | The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. | 33 |
Citation
Dessen P
DCAF7 (DDB1 and CUL4 associated factor 7)
Atlas Genet Cytogenet Oncol Haematol. 2011-11-01
Online version: http://atlasgeneticsoncology.org/gene/52484/dcaf7-(ddb1-and-cul4-associated-factor-7)
