GCGR (glucagon receptor)

2011-12-01  

Identity

HGNC
GCGR
LOCATION
17q25.3
LOCUSID
2642
ALIAS
GGR,GL-R,MVAH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2642
MIM: 138033
HGNC: 4192
Ensembl: ENSG00000215644

Variants:

dbSNP: 2642
ClinVar: 2642
TCGA: ENSG00000215644
COSMIC: GCGR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215644ENST00000400723P47871
ENSG00000215644ENST00000570996I3L454
ENSG00000215644ENST00000573428I3L1L8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359

References

Pubmed IDYearTitleCitations
384242422024The renal glucagon receptor is essential to kidney metabolic and homeostatic functions.1
384242422024The renal glucagon receptor is essential to kidney metabolic and homeostatic functions.1
357183392022Hepatocyte cholesterol content modulates glucagon receptor signalling.5
357673252022Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes.4
357845652022Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes.6
357183392022Hepatocyte cholesterol content modulates glucagon receptor signalling.5
357673252022Glucagon receptor-mediated regulation of gluconeogenic gene transcription is endocytosis-dependent in primary hepatocytes.4
357845652022Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes.6
333690252021Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for (19) F-NMR studies in solution.5
339200242021Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery.5
342712202021Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.14
333690252021Design and preparation of the class B G protein-coupled receptors GLP-1R and GCGR for (19) F-NMR studies in solution.5
339200242021Ligand-Receptor Interactions and Machine Learning in GCGR and GLP-1R Drug Discovery.5
342712202021Receptor Activity-Modifying Protein 2 (RAMP2) alters glucagon receptor trafficking in hepatocytes with functional effects on receptor signalling.14
321933222020Structural basis of G(s) and G(i) recognition by the human glucagon receptor.73

Citation

Dessen P

GCGR (glucagon receptor)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52502/css/lib/gene-explorer/humanGenome