GCGR (glucagon receptor)

2011-12-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
GGR,GL-R,MVAH
FUSION GENES

Other Information

Locus ID:

NCBI: 2642
MIM: 138033
HGNC: 4192
Ensembl: ENSG00000215644

Variants:

dbSNP: 2642
ClinVar: 2642
TCGA: ENSG00000215644
COSMIC: GCGR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000215644ENST00000400723P47871
ENSG00000215644ENST00000570996I3L454
ENSG00000215644ENST00000573428I3L1L8

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glucagon signaling pathwayKEGGhsa04922
Glucagon signaling pathwayKEGGko04922
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class B/2 (Secretin family receptors)REACTOMER-HSA-373080
Glucagon-type ligand receptorsREACTOMER-HSA-420092
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Glucagon signaling in metabolic regulationREACTOMER-HSA-163359

References

Pubmed IDYearTitleCitations
271115102016Extra-helical binding site of a glucagon receptor antagonist.55
285144512017Structure of the full-length glucagon class B G-protein-coupled receptor.44
262277982015Conformational states of the full-length glucagon receptor.42
127243312003Three distinct epitopes on the extracellular face of the glucagon receptor determine specificity for the glucagon amino terminus.25
293000132018Structure of the glucagon receptor in complex with a glucagon analogue.20
231853672012Anti-diabetic efficacy and impact on amino acid metabolism of GRA1, a novel small-molecule glucagon receptor antagonist.18
272266002016Differential Requirement of the Extracellular Domain in Activation of Class B G Protein-coupled Receptors.15
254519422015Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking.14
256958902015Glucagon cell hyperplasia and neoplasia with and without glucagon receptor mutations.10
206473072010Mutational and cysteine scanning analysis of the glucagon receptor N-terminal domain.9

Citation

Dessen P

GCGR (glucagon receptor)

Atlas Genet Cytogenet Oncol Haematol. 2011-12-01

Online version: http://atlasgeneticsoncology.org/gene/52502/gcgr-(glucagon-receptor)