LCOR (ligand dependent nuclear receptor corepressor)

2012-01-01  

Identity

HGNC
LOCATION
10q24.1
LOCUSID
ALIAS
C10orf12,MLR2

Other Information

Locus ID:

NCBI: 84458
MIM: 607698
HGNC: 29503
Ensembl: ENSG00000196233

Variants:

dbSNP: 84458
ClinVar: 84458
TCGA: ENSG00000196233
COSMIC: LCOR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000196233ENST00000286067A0A1P0AZG4
ENSG00000196233ENST00000356016Q96JN0
ENSG00000196233ENST00000371097Q96JN0
ENSG00000196233ENST00000371103Q96JN0
ENSG00000196233ENST00000421806Q96JN0
ENSG00000196233ENST00000540664Q96JN0

Expression (GTEx)

0
1
2
3
4
5
6
7

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125355282003Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms.83
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
285306572017Normal and cancerous mammary stem cells evade interferon-induced constraint through the miR-199a-LCOR axis.33
197449312009Function of histone deacetylase 6 as a cofactor of nuclear receptor coregulator LCoR.26
222776512012Ligand-dependent corepressor (LCoR) recruitment by Kruppel-like factor 6 (KLF6) regulates expression of the cyclin-dependent kinase inhibitor CDKN1A gene.20
218567472011Ligand-dependent corepressor acts as a novel androgen receptor corepressor, inhibits prostate cancer growth, and is functionally inactivated by the Src protein kinase.19
197449322009Ligand-dependent corepressor LCoR is an attenuator of progesterone-regulated gene expression.18
215658922011miR-615-3p promotes the phagocytic capacity of splenic macrophages by targeting ligand-dependent nuclear receptor corepressor in cirrhosis-related portal hypertension.15
284143082017Complex regulation of LCoR signaling in breast cancer cells.10
311865332019C10ORF12 modulates PRC2 histone methyltransferase activity and H3K27me3 levels.0

Citation

Dessen P

LCOR (ligand dependent nuclear receptor corepressor)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52507/lcor-(ligand-dependent-nuclear-receptor-corepressor)