Identity
HGNC
LOCATION
7q21.11
LOCUSID
ALIAS
GLUR3,GPRC1C,MGLUR3,mGlu3
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2913
MIM: 601115
HGNC: 4595
Ensembl: ENSG00000198822
Variants:
dbSNP: 2913
ClinVar: 2913
TCGA: ENSG00000198822
COSMIC: GRM3
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA444460 | Heroin Dependence | Disease | ClinicalAnnotation, Literature, MultilinkAnnotation | associated | 24498053 | ||
| PA447216 | Schizophrenia | Disease | ClinicalAnnotation | associated | PD | 19451915, 25096017, 25209194 | |
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 19451915 | |
| PA452233 | antipsychotics | Chemical | ClinicalAnnotation | associated | PD | 25096017, 25209194 | |
| PA452619 | heroin | Chemical | ClinicalAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34290229 | 2021 | Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. | 10 |
| 34290229 | 2021 | Inhibition of metabotropic glutamate receptor III facilitates sensitization to alkylating chemotherapeutics in glioblastoma. | 10 |
| 31925813 | 2020 | Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis. | 21 |
| 32581155 | 2020 | Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line. | 2 |
| 32839935 | 2020 | Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis. | 11 |
| 31925813 | 2020 | Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis. | 21 |
| 32581155 | 2020 | Internalization of AMPA-type Glutamate Receptor in the MIN6 Pancreatic β-cell Line. | 2 |
| 32839935 | 2020 | Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis. | 11 |
| 28646617 | 2018 | Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling. | 7 |
| 30102917 | 2018 | Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3. | 15 |
| 30488581 | 2018 | Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival. | 9 |
| 28646617 | 2018 | Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling. | 7 |
| 30102917 | 2018 | Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3. | 15 |
| 30488581 | 2018 | Clinical significance of glutamate metabotropic receptors in renal cell carcinoma risk and survival. | 9 |
| 28114282 | 2017 | The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis. | 15 |
Citation
Dessen P
GRM3 (glutamate metabotropic receptor 3)
Atlas Genet Cytogenet Oncol Haematol. 2012-01-01
Online version: http://atlasgeneticsoncology.org/gene/52514/grm3-(glutamate-metabotropic-receptor-3)
