GLYAT (glycine-N-acyltransferase)

2011-07-01  

Identity

HGNC
GLYAT
LOCATION
11q12.1
LOCUSID
10249
ALIAS
ACGNAT,CAT,GAT
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10249
MIM: 607424
HGNC: 13734
Ensembl: ENSG00000149124

Variants:

dbSNP: 10249
ClinVar: 10249
TCGA: ENSG00000149124
COSMIC: GLYAT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149124ENST00000278400Q6IB77
ENSG00000149124ENST00000344743Q6IB77
ENSG00000149124ENST00000344743A0A384P5E3
ENSG00000149124ENST00000529732Q6IB77
ENSG00000149124ENST00000529732A0A384P5E3
ENSG00000149124ENST00000586098K7ES21
ENSG00000149124ENST00000611865Q6IB77
ENSG00000149124ENST00000611865A0A384P5E3

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Phenylalanine metabolismKEGGko00360
Phenylalanine metabolismKEGGhsa00360
MetabolismREACTOMER-HSA-1430728
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Amino Acid conjugationREACTOMER-HSA-156587
Conjugation of carboxylic acidsREACTOMER-HSA-159424
Conjugation of benzoate with glycineREACTOMER-HSA-177135
Conjugation of salicylate with glycineREACTOMER-HSA-177128

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
335672942021Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism.4
338039162021Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA.1
335672942021Frequent sequence variants of human glycine N-acyltransferase (GLYAT) and inborn errors of metabolism.4
338039162021Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl-CoA.1
287591632017New insights into the catalytic mechanism of human glycine N-acyltransferase.4
287591632017New insights into the catalytic mechanism of human glycine N-acyltransferase.4
261496502015Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway.10
261496502015Conservation of the coding regions of the glycine N-acyltransferase gene further suggests that glycine conjugation is an essential detoxification pathway.10
231089852013Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.26
232377812013Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase.7
231089852013Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.26
232377812013Characterisation of the influence of genetic variations on the enzyme activity of a recombinant human glycine N-acyltransferase.7
224754852012Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma.18
224754852012Designation of enzyme activity of glycine-N-acyltransferase family genes and depression of glycine-N-acyltransferase in human hepatocellular carcinoma.18
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20

Citation

Dessen P

GLYAT (glycine-N-acyltransferase)

Atlas Genet Cytogenet Oncol Haematol. 2011-07-01

Online version: http://atlasgeneticsoncology.org/gene/52524/glyat-(glycine-n-acyltransferase)