Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5723
MIM: 172480
HGNC: 9577
Ensembl: ENSG00000146733
Variants:
dbSNP: 5723
ClinVar: 5723
TCGA: ENSG00000146733
COSMIC: PSPH
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA450423 | l-methionine | Chemical | Literature, MultilinkAnnotation | associated | 24651765 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 33674745 | 2021 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. | 13 |
| 33674745 | 2021 | PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1. | 13 |
| 30662358 | 2019 | PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways. | 14 |
| 31205021 | 2019 | Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase. | 7 |
| 31446747 | 2019 | Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway. | 10 |
| 30662358 | 2019 | PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways. | 14 |
| 31205021 | 2019 | Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase. | 7 |
| 31446747 | 2019 | Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway. | 10 |
| 28476802 | 2017 | Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. | 21 |
| 28476802 | 2017 | Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. | 21 |
| 25080166 | 2015 | Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan. | 4 |
| 25793315 | 2015 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. | 152 |
| 25080166 | 2015 | Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan. | 4 |
| 25793315 | 2015 | cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions. | 152 |
| 25152457 | 2014 | Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway. | 44 |
Citation
Dessen P
PSPH (phosphoserine phosphatase)
Atlas Genet Cytogenet Oncol Haematol. 2012-01-01
Online version: http://atlasgeneticsoncology.org/gene/52528/psph-(phosphoserine-phosphatase)
