HOXB2 (homeobox B2)

2012-01-01  

Identity

HGNC
HOXB2
LOCATION
17q21.32
LOCUSID
3212
ALIAS
HOX2,HOX2H,Hox-2.8,K8

Other Information

Locus ID:

NCBI: 3212
MIM: 142967
HGNC: 5113
Ensembl: ENSG00000173917

Variants:

dbSNP: 3212
ClinVar: 3212
TCGA: ENSG00000173917
COSMIC: HOXB2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173917ENST00000330070P14652

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Developmental BiologyREACTOMER-HSA-1266738
Activation of HOX genes during differentiationREACTOMER-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesisREACTOMER-HSA-5617472

References

Pubmed IDYearTitleCitations
201955142010Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.31
206286242010Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".29
194779232009Induction of HoxB transcription by retinoic acid requires actin polymerization.23
128022762003Regulation of Hoxb2 by APL-associated PLZF protein.15
264828522015The role of HOXB2 and HOXB3 in acute myeloid leukemia.12
216726232011A functional in vivo screen for regulators of tumor progression identifies HOXB2 as a regulator of tumor growth in breast cancer.9
257437972015Increased expression of HOXB2 and HOXB13 proteins is associated with HPV infection and cervical cancer progression.5
311160902019Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2.5
178050562007HOXB2 as a novel prognostic indicator for stage I lung adenocarcinomas.4
306048552018Lung cancer susceptibility genetic variants modulate HOXB2 expression in the lung.3

Citation

Dessen P

HOXB2 (homeobox B2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52538/hoxb2-(homeobox-b2)