Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 435
MIM: 608310
HGNC: 746
Ensembl: ENSG00000126522
Variants:
dbSNP: 435
ClinVar: 435
TCGA: ENSG00000126522
COSMIC: ASL
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166176020 | sodium benzoate / sodium phenylacetate | Chemical | LabelAnnotation | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37490345 | 2023 | Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide-mediated dysregulation of claudin expression. | 1 |
| 37490345 | 2023 | Argininosuccinate lyase deficiency causes blood-brain barrier disruption via nitric oxide-mediated dysregulation of claudin expression. | 1 |
| 33846069 | 2021 | Biomarkers for liver disease in urea cycle disorders. | 6 |
| 33851512 | 2021 | Variants associated with urea cycle disorders in Japanese patients: Nationwide study and literature review. | 5 |
| 33846069 | 2021 | Biomarkers for liver disease in urea cycle disorders. | 6 |
| 33851512 | 2021 | Variants associated with urea cycle disorders in Japanese patients: Nationwide study and literature review. | 5 |
| 31943503 | 2020 | From genotype to phenotype: Early prediction of disease severity in argininosuccinic aciduria. | 9 |
| 32410394 | 2020 | Clinical and genetic analysis of five Chinese patients with urea cycle disorders. | 3 |
| 31943503 | 2020 | From genotype to phenotype: Early prediction of disease severity in argininosuccinic aciduria. | 9 |
| 32410394 | 2020 | Clinical and genetic analysis of five Chinese patients with urea cycle disorders. | 3 |
| 31018905 | 2019 | KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL. | 17 |
| 31183366 | 2019 | Whole-Exome Sequencing Identified a Novel Compound Heterozygous Genotype in ASL in a Chinese Han Patient with Argininosuccinate Lyase Deficiency. | 0 |
| 31018905 | 2019 | KLF7 promotes polyamine biosynthesis and glioma development through transcriptionally activating ASL. | 17 |
| 31183366 | 2019 | Whole-Exome Sequencing Identified a Novel Compound Heterozygous Genotype in ASL in a Chinese Han Patient with Argininosuccinate Lyase Deficiency. | 0 |
| 27840980 | 2017 | Silencing of argininosuccinate lyase inhibits colorectal cancer formation. | 13 |
Citation
Dessen P
ASL (argininosuccinate lyase)
Atlas Genet Cytogenet Oncol Haematol. 2012-01-01
Online version: http://atlasgeneticsoncology.org/gene/52543/asl-(argininosuccinate-lyase)
