ILF2 (interleukin enhancer binding factor 2)

2012-01-01  

Identity

HGNC
ILF2
LOCATION
1q21.3
LOCUSID
3608
ALIAS
NF45,PRO3063
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3608
MIM: 603181
HGNC: 6037
Ensembl: ENSG00000143621

Variants:

dbSNP: 3608
ClinVar: 3608
TCGA: ENSG00000143621
COSMIC: ILF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143621ENST00000361891Q12905
ENSG00000143621ENST00000361891F4ZW62
ENSG00000143621ENST00000368681A0A0A0MRL0
ENSG00000143621ENST00000368684X6R6Z1
ENSG00000143621ENST00000615950B4DY09

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
193985782009The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway.91
184580582008Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control.53
158171562005NF45/ILF2 tissue expression, promoter analysis, and interleukin-2 transactivating function.31
200515142010NF45 and NF90 regulate HS4-dependent interleukin-13 transcription in T cells.30
219696022011The NF90/NF45 complex participates in DNA break repair via nonhomologous end joining.30
198935742010NF45 functions as an IRES trans-acting factor that is required for translation of cIAP1 during the unfolded protein response.27
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
286694902017ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma.25
218236642011Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein.23
305555732018Long non-coding RNA DANCR stabilizes HIF-1α and promotes metastasis by interacting with NF90/NF45 complex in nasopharyngeal carcinoma.22

Citation

Dessen P

ILF2 (interleukin enhancer binding factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52546/ilf2-(interleukin-enhancer-binding-factor-2)