ASCC3 (activating signal cointegrator 1 complex subunit 3)

2012-01-01  

Identity

HGNC
ASCC3
LOCATION
6q16.3
LOCUSID
10973
ALIAS
ASC1p200,HELIC1,RNAH
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10973
MIM: 614217
HGNC: 18697
Ensembl: ENSG00000112249

Variants:

dbSNP: 10973
ClinVar: 10973
TCGA: ENSG00000112249
COSMIC: ASCC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112249ENST00000324696J3KNJ4
ENSG00000112249ENST00000324723E5RFZ0
ENSG00000112249ENST00000369143Q8N3C0
ENSG00000112249ENST00000369162Q8N3C0
ENSG00000112249ENST00000522650Q8N3C0

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
DNA RepairREACTOMER-HSA-73894
DNA Damage ReversalREACTOMER-HSA-73942
Reversal of alkylation damage by DNA dioxygenasesREACTOMER-HSA-73943
ALKBH3 mediated reversal of alkylation damageREACTOMER-HSA-112126

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381481152023ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.2
381481152023ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.2
342173092021ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.10
342173092021ALKBH3 partner ASCC3 mediates P-body formation and selective clearance of MMS-induced 1-methyladenosine and 3-methylcytosine from mRNA.10
331396972020The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.12
331396972020The interaction of DNA repair factors ASCC2 and ASCC3 is affected by somatic cancer mutations.12
282157062017UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.97
282157062017UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.97
265366292015Correlations between ASCC3 Gene Polymorphisms and Chronic Hepatitis B in a Chinese Han Population.3
265366292015Correlations between ASCC3 Gene Polymorphisms and Chronic Hepatitis B in a Chinese Han Population.3
237810712013A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response.72
237810712013A short hairpin RNA screen of interferon-stimulated genes identifies a novel negative regulator of the cellular antiviral response.72
220551842011DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.108
220551842011DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation.108
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

ASCC3 (activating signal cointegrator 1 complex subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52547/ascc3-(activating-signal-cointegrator-1-complex-subunit-3)