Identity
HGNC
LOCATION
1p33
LOCUSID
ALIAS
CK,CMK,CMPK,UMK,UMP-CMPK,UMPK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 51727
MIM: 191710
HGNC: 18170
Ensembl: ENSG00000162368
Variants:
dbSNP: 51727
ClinVar: 51727
TCGA: ENSG00000162368
COSMIC: CMPK1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000162368 | ENST00000371871 | Q5T0D2 |
| ENSG00000162368 | ENST00000371873 | P30085 |
| ENSG00000162368 | ENST00000450808 | A0A494BXC7 |
| ENSG00000162368 | ENST00000471289 | E9PJD2 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | ClinicalAnnotation | associated | PD | 21642870 | |
| PA445062 | Neoplasms | Disease | ClinicalAnnotation | associated | PK | PD | 21642870, 22838949, 22838950, 24361227 |
| PA445218 | Pancreatic Neoplasms | Disease | ClinicalAnnotation | associated | PD | 22838950 | |
| PA449014 | cisplatin | Chemical | ClinicalAnnotation | associated | PD | 21642870 | |
| PA449748 | gemcitabine | Chemical | ClinicalAnnotation | associated | PK | PD | 21642870, 22838949, 22838950, 24361227 |
| PA450163 | lamivudine | Chemical | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37258394 | 2023 | Twenty-Four Percent of Wildland Firefighters Reach Critical Levels of Serum Creatine Kinase During 80-Hour Critical Training. | 0 |
| 37258394 | 2023 | Twenty-Four Percent of Wildland Firefighters Reach Critical Levels of Serum Creatine Kinase During 80-Hour Critical Training. | 0 |
| 31201869 | 2019 | MiR-3613-3p impairs IFN-induced immune response by targeting CMPK1 in chronic hepatitis B. | 3 |
| 31201869 | 2019 | MiR-3613-3p impairs IFN-induced immune response by targeting CMPK1 in chronic hepatitis B. | 3 |
| 28414100 | 2017 | Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer. | 21 |
| 28414100 | 2017 | Cytidine monophosphate kinase is inhibited by the TGF-β signalling pathway through the upregulation of miR-130b-3p in human epithelial ovarian cancer. | 21 |
| 27558661 | 2016 | Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients. | 9 |
| 27558661 | 2016 | Prognostic significance of nuclear expression of UMP-CMP kinase in triple negative breast cancer patients. | 9 |
| 25659034 | 2015 | The contribution of CMP kinase to the efficiency of DNA repair. | 6 |
| 25659034 | 2015 | The contribution of CMP kinase to the efficiency of DNA repair. | 6 |
| 24963161 | 2014 | CMPK1 and RBP3 are associated with corneal curvature in Asian populations. | 13 |
| 24963161 | 2014 | CMPK1 and RBP3 are associated with corneal curvature in Asian populations. | 13 |
| 22838950 | 2012 | Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine. | 7 |
| 22838950 | 2012 | Effect of genetic polymorphisms on therapeutic response and clinical outcomes in pancreatic cancer patients treated with gemcitabine. | 7 |
| 21559290 | 2011 | UMP/CMPK is not the critical enzyme in the metabolism of pyrimidine ribonucleotide and activation of deoxycytidine analogs in human RKO cells. | 3 |
Citation
Dessen P
CMPK1 (cytidine/uridine monophosphate kinase 1)
Atlas Genet Cytogenet Oncol Haematol. 2012-01-01
Online version: http://atlasgeneticsoncology.org/gene/52552/cmpk1-(cytidine-uridine-monophosphate-kinase-1)
