VIPR2 (vasoactive intestinal peptide receptor 2)

2012-01-01  

Identity

HGNC
VIPR2
LOCATION
7q36.3
LOCUSID
7434
ALIAS
C16DUPq36.3,DUP7q36.3,PACAP-R-3,PACAP-R3,VIP-R-2,VPAC2,VPAC2R,VPCAP2R
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7434
MIM: 601970
HGNC: 12695
Ensembl: ENSG00000106018

Variants:

dbSNP: 7434
ClinVar: 7434
TCGA: ENSG00000106018
COSMIC: VIPR2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106018ENST00000262178P41587
ENSG00000106018ENST00000262178X5D7Q6
ENSG00000106018ENST00000377633P41587
ENSG00000106018ENST00000402066C9JCP7
ENSG00000106018ENST00000421760E9PCR5

Expression (GTEx)

0
5
10
15
20
25
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366037702023Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.2
376956052023TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.1
378078482023Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.0
382224532023Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.0
366037702023Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.2
376956052023TMEM132D and VIPR2 Polymorphisms as Genetic Risk Loci for Retinal Detachment: A Genome-Wide Association Study and Polygenic Risk Score Analysis.1
378078482023Seaweed intake modulates the association between VIPR2 variants and the incidence of metabolic syndrome in middle-aged Koreans.0
382224532023Outdoor time influences VIPR2 polymorphism rs2071623 to regulate axial length in Han Chinese children.0
333181352022Dysfunction of VIPR2 leads to myopia in humans and mice.9
353537982022Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.2
363324702022AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.4
364302752022PAC(1), VPAC(1), and VPAC(2) Receptor Expression in Rat and Human Trigeminal Ganglia: Characterization of PACAP-Responsive Receptor Antibodies.1
333181352022Dysfunction of VIPR2 leads to myopia in humans and mice.9
353537982022Identification of rare mutations of the vasoactive intestinal peptide receptor 2 gene in schizophrenia.2
363324702022AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys(25)-Cys(192)) formation of functional significance for VIPR2.4

Citation

Dessen P

VIPR2 (vasoactive intestinal peptide receptor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52563/vipr2-(vasoactive-intestinal-peptide-receptor-2)