SECTM1 (secreted and transmembrane 1)

2012-02-01  

Identity

HGNC
LOCATION
17q25.3
LOCUSID
ALIAS
K12,SECTM
FUSION GENES

Other Information

Locus ID:

NCBI: 6398
MIM: 602602
HGNC: 10707
Ensembl: ENSG00000141574

Variants:

dbSNP: 6398
ClinVar: 6398
TCGA: ENSG00000141574
COSMIC: SECTM1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141574ENST00000269389Q8WVN6
ENSG00000141574ENST00000580437J3QQU6
ENSG00000141574ENST00000581691J3KTR4
ENSG00000141574ENST00000581864J3QR99
ENSG00000141574ENST00000581954J3QRU5
ENSG00000141574ENST00000582290J3KS40
ENSG00000141574ENST00000582563J3QKK2
ENSG00000141574ENST00000583093J3KSN0

Expression (GTEx)

0
50
100
150
200

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
381641822024SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFβ1/Smad signaling pathway.1
381641822024SECTM1 promotes the development of glioblastoma and mesenchymal transition by regulating the TGFβ1/Smad signaling pathway.1
241574612014SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.19
242112522014Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7.3
241574612014SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway.19
242112522014Autocrine GM-CSF transcription in the leukemic progenitor cell line KG1a is mediated by the transcription factor ETS1 and is negatively regulated through SECTM1 mediated ligation of CD7.3
217499092011The T/NK cell co-stimulatory molecule SECTM1 is an IFN "early response gene" that is negatively regulated by LPS in human monocytic cells.15
217499092011The T/NK cell co-stimulatory molecule SECTM1 is an IFN "early response gene" that is negatively regulated by LPS in human monocytic cells.15
204069642010Risk of meningioma and common variation in genes related to innate immunity.21
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.12
204069642010Risk of meningioma and common variation in genes related to innate immunity.21
204387852010Polymorphisms in innate immunity genes and risk of childhood leukemia.12
194235402009Common variation in genes related to innate immunity and risk of adult glioma.35
194235402009Common variation in genes related to innate immunity and risk of adult glioma.35

Citation

Dessen P

SECTM1 (secreted and transmembrane 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52581/sectm1-(secreted-and-transmembrane-1)