NCK2 (NCK adaptor protein 2)

2012-02-01  

Identity

HGNC
LOCATION
2q12.2
LOCUSID
ALIAS
GRB4,NCKbeta
FUSION GENES

Other Information

Locus ID:

NCBI: 8440
MIM: 604930
HGNC: 7665
Ensembl: ENSG00000071051

Variants:

dbSNP: 8440
ClinVar: 8440
TCGA: ENSG00000071051
COSMIC: NCK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071051ENST00000233154O43639
ENSG00000071051ENST00000233154A0A0S2Z4M6
ENSG00000071051ENST00000393348E7EPF5
ENSG00000071051ENST00000393349O43639
ENSG00000071051ENST00000393349A0A0S2Z4M6
ENSG00000071051ENST00000425756E9PEE2
ENSG00000071051ENST00000451463E7ERP6
ENSG00000071051ENST00000522586E7ERP6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
ErbB signaling pathwayKEGGko04012
Axon guidanceKEGGko04360
T cell receptor signaling pathwayKEGGko04660
Pathogenic Escherichia coli infectionKEGGko05130
ErbB signaling pathwayKEGGhsa04012
Axon guidanceKEGGhsa04360
T cell receptor signaling pathwayKEGGhsa04660
Pathogenic Escherichia coli infectionKEGGhsa05130
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
Cell-Cell communicationREACTOMER-HSA-1500931
Nephrin interactionsREACTOMER-HSA-373753
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Signaling by Robo receptorREACTOMER-HSA-376176
Activation of RacREACTOMER-HSA-428540
EPH-Ephrin signalingREACTOMER-HSA-2682334
Ephrin signalingREACTOMER-HSA-3928664

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365040512022[CBL inhibits proliferation and invasion of breast cancer cells by ubiquitylation-mediated degradation of NCK2].0
365040512022[CBL inhibits proliferation and invasion of breast cancer cells by ubiquitylation-mediated degradation of NCK2].0
339172272021Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.5
339172272021Cooperative Interaction of Nck and Lck Orchestrates Optimal TCR Signaling.5
315120422019Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea.3
316387422019Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.12
315120422019Association of HK2 and NCK2 with normal-tension glaucoma in a population from the Republic of Korea.3
316387422019Nck adapter proteins promote podosome biogenesis facilitating extracellular matrix degradation and cancer invasion.12
292186932018Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer.4
292186932018Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer.4
299118352017A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.0
299118352017A Study of Interleukin-2 Production and Nck Adaptor Molecule Gene Expression in Systemic Lupus Erythematosus Patients.0
270337052016Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.11
270337052016Nephrin Suppresses Hippo Signaling through the Adaptor Proteins Nck and WTIP.11
260040082015Targeting of the EGFR/β1 integrin connecting proteins PINCH1 and Nck2 radiosensitizes three-dimensional SCC cell cultures.3

Citation

Dessen P

NCK2 (NCK adaptor protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52582/nck2-(nck-adaptor-protein-2)