SLC39A3 (solute carrier family 39 member 3)

2012-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
ZIP-3,ZIP3
FUSION GENES

Other Information

Locus ID:

NCBI: 29985
MIM: 612168
HGNC: 17128
Ensembl: ENSG00000141873

Variants:

dbSNP: 29985
ClinVar: 29985
TCGA: ENSG00000141873
COSMIC: SLC39A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141873ENST00000269740Q9BRY0
ENSG00000141873ENST00000455372Q9BRY0
ENSG00000141873ENST00000545664F5H385
ENSG00000141873ENST00000589166K7ENJ1
ENSG00000141873ENST00000589363K7EJZ1

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
224271552012Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.25
224271552012Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.25
210530942011Expression of the zinc transporters genes and metallothionein in obese women.5
216138272011Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.34
210530942011Expression of the zinc transporters genes and metallothionein in obese women.5
216138272011Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.34
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.34
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.34
182790332008Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.38
182790332008Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.38
175506122007hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.62
175506122007hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.62
145259872003Structure, function, and regulation of a subfamily of mouse zinc transporter genes.56
145259872003Structure, function, and regulation of a subfamily of mouse zinc transporter genes.56

Citation

Dessen P

SLC39A3 (solute carrier family 39 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52588/slc39a3-(solute-carrier-family-39-member-3)