SLC39A3 (solute carrier family 39 member 3)

2012-02-01  

Identity

HGNC
SLC39A3
LOCATION
19p13.3
LOCUSID
29985
ALIAS
ZIP-3,ZIP3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 29985
MIM: 612168
HGNC: 17128
Ensembl: ENSG00000141873

Variants:

dbSNP: 29985
ClinVar: 29985
TCGA: ENSG00000141873
COSMIC: SLC39A3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141873ENST00000269740Q9BRY0
ENSG00000141873ENST00000455372Q9BRY0
ENSG00000141873ENST00000545664F5H385
ENSG00000141873ENST00000589166K7ENJ1
ENSG00000141873ENST00000589363K7EJZ1

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compoundsREACTOMER-HSA-425366
Metal ion SLC transportersREACTOMER-HSA-425410
Zinc transportersREACTOMER-HSA-435354
Zinc influx into cells by the SLC39 gene familyREACTOMER-HSA-442380

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
224271552012Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.25
224271552012Evidence for changes in RREB-1, ZIP3, and Zinc in the early development of pancreatic adenocarcinoma.25
210530942011Expression of the zinc transporters genes and metallothionein in obese women.5
216138272011Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.34
210530942011Expression of the zinc transporters genes and metallothionein in obese women.5
216138272011Decreased zinc and downregulation of ZIP3 zinc uptake transporter in the development of pancreatic adenocarcinoma.34
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.34
193080212009Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.34
182790332008Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.38
182790332008Zinc supplementation in the elderly reduces spontaneous inflammatory cytokine release and restores T cell functions.38
175506122007hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.62
175506122007hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands.62
145259872003Structure, function, and regulation of a subfamily of mouse zinc transporter genes.56
145259872003Structure, function, and regulation of a subfamily of mouse zinc transporter genes.56

Citation

Dessen P

SLC39A3 (solute carrier family 39 member 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52588/slc39a3-(solute-carrier-family-39-member-3)