SAE1 (SUMO1 activating enzyme subunit 1)

2012-02-01  

Identity

HGNC
SAE1
LOCATION
19q13.32
LOCUSID
10055
ALIAS
AOS1,HSPC140,SUA1,UBLE1A
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10055
MIM: 613294
HGNC: 30660
Ensembl: ENSG00000142230

Variants:

dbSNP: 10055
ClinVar: 10055
TCGA: ENSG00000142230
COSMIC: SAE1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000142230ENST00000270225Q9UBE0
ENSG00000142230ENST00000270225A0A024R0R4
ENSG00000142230ENST00000392776Q9UBE0
ENSG00000142230ENST00000413379Q9UBE0
ENSG00000142230ENST00000414294B3KNJ4
ENSG00000142230ENST00000594144M0R054
ENSG00000142230ENST00000594526M0R286
ENSG00000142230ENST00000596995M0R375
ENSG00000142230ENST00000597808M0QYM8
ENSG00000142230ENST00000598840M0QZS6
ENSG00000142230ENST00000600706M0QX65
ENSG00000142230ENST00000600753M0QYP2
ENSG00000142230ENST00000659110A0A590UKA0
ENSG00000142230ENST00000660039A0A590UK93
ENSG00000142230ENST00000664120A0A590UKC5

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ubiquitin mediated proteolysisKEGGko04120
Ubiquitin mediated proteolysisKEGGhsa04120
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
SUMOylationREACTOMER-HSA-2990846
Processing and activation of SUMOREACTOMER-HSA-3215018
SUMO is conjugated to E1 (UBA2:SAE1)REACTOMER-HSA-3065676
SUMO is transferred from E1 to E2 (UBE2I, UBC9)REACTOMER-HSA-3065678

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383510142024ROS-mediated up-regulation of SAE1 by Helicobacter pylori promotes human gastric tumor genesis and progression.1
383510142024ROS-mediated up-regulation of SAE1 by Helicobacter pylori promotes human gastric tumor genesis and progression.1
367481932023Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation.3
377050412023Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation.2
367481932023Increased Small Ubiquitin-like Modifier-Activating Enzyme SAE1 Promotes Hepatocellular Carcinoma by Enhancing mTOR SUMOylation.3
377050412023Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation.2
334773332021SUMO-Activating Enzyme Subunit 1 (SAE1) Is a Promising Diagnostic Cancer Metabolism Biomarker of Hepatocellular Carcinoma.15
344148862021An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.12
334773332021SUMO-Activating Enzyme Subunit 1 (SAE1) Is a Promising Diagnostic Cancer Metabolism Biomarker of Hepatocellular Carcinoma.15
344148862021An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens.12
322492122020SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.11
329388302020Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes.14
322492122020SUMOylation of the transcription factor ZFHX3 at Lys-2806 requires SAE1, UBC9, and PIAS2 and enhances its stability and function in cell proliferation.11
329388302020Increased SUMO-activating enzyme SAE1/UBA2 promotes glycolysis and pathogenic behavior of rheumatoid fibroblast-like synoviocytes.14
313452252019SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways.25

Citation

Dessen P

SAE1 (SUMO1 activating enzyme subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52591/sae1-(sumo1-activating-enzyme-subunit-1)