VPS35 (VPS35 retromer complex component)

2012-02-01  

Identity

HGNC
VPS35
LOCATION
16q11.2
LOCUSID
55737
ALIAS
MEM3,PARK17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55737
MIM: 601501
HGNC: 13487
Ensembl: ENSG00000069329

Variants:

dbSNP: 55737
ClinVar: 55737
TCGA: ENSG00000069329
COSMIC: VPS35

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000069329ENST00000299138Q96QK1
ENSG00000069329ENST00000568612I3L4S0
ENSG00000069329ENST00000568784H3BRJ7
ENSG00000069329ENST00000640313A0A1W2PP10
ENSG00000069329ENST00000647959A0A3B3ITD4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
WNT ligand biogenesis and traffickingREACTOMER-HSA-3238698

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379500402024VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.0
383689302024VPS35 and retromer dysfunction in Parkinson's disease.1
384093922024The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease.0
379500402024VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.0
383689302024VPS35 and retromer dysfunction in Parkinson's disease.1
384093922024The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease.0
367384812023VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer.5
367384812023VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer.5
346139182022Structural and Functional Impact of Damaging Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) on Human VPS35 Protein Using Computational Approaches.2
356906722022ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells.2
357668792022Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway.0
346139182022Structural and Functional Impact of Damaging Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) on Human VPS35 Protein Using Computational Approaches.2
356906722022ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells.2
357668792022Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway.0
331420122021Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.22

Citation

Dessen P

VPS35 (VPS35 retromer complex component)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52597/vps35-(vps35-retromer-complex-component)