MAST2 (microtubule associated serine/threonine kinase 2)

2012-02-01  

Identity

HGNC
LOCATION
1p34.1
LOCUSID
ALIAS
MAST205,MTSSK
FUSION GENES

Other Information

Locus ID:

NCBI: 23139
MIM: 612257
HGNC: 19035
Ensembl: ENSG00000086015

Variants:

dbSNP: 23139
ClinVar: 23139
TCGA: ENSG00000086015
COSMIC: MAST2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000086015ENST00000361297Q6P0Q8
ENSG00000086015ENST00000372008V9GXZ1
ENSG00000086015ENST00000372009E7ERL6

Expression (GTEx)

0
50
100
150

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
221017662011Functionally recurrent rearrangements of the MAST kinase and Notch gene families in breast cancer.142
196358442009Exon-trapping mediated by the human retrotransposon SVA.47
199614232009Novel family of human transposable elements formed due to fusion of the first exon of gene MAST2 with retrotransposon SVA.23
226090642012Transcriptional regulation of human-specific SVAF₁ retrotransposons by cis-regulatory MAST2 sequences.11
235044572013MAST205 competes with cystic fibrosis transmembrane conductance regulator (CFTR)-associated ligand for binding to CFTR to regulate CFTR-mediated fluid transport.7
262031792015A Screen for Genomic Disorders of Infertility Identifies MAST2 Duplications Associated with Nonobstructive Azoospermia in Humans.6
241404252013MAST2 and NOTCH1 translocations in breast carcinoma and associated pre-invasive lesions.5
259420572015Deciphering the unconventional peptide binding to the PDZ domain of MAST2.3

Citation

Dessen P

MAST2 (microtubule associated serine/threonine kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-02-01

Online version: http://atlasgeneticsoncology.org/gene/52599/mast2-(microtubule-associated-serine-threonine-kinase-2)