AMOTL1 (angiomotin like 1)

2012-03-01  

Identity

HGNC
AMOTL1
LOCATION
11q21
LOCUSID
154810
ALIAS
JEAP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 154810
MIM: 614657
HGNC: 17811
Ensembl: ENSG00000166025

Variants:

dbSNP: 154810
ClinVar: 154810
TCGA: ENSG00000166025
COSMIC: AMOTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166025ENST00000299004F8WDH4
ENSG00000166025ENST00000317829Q8IY63
ENSG00000166025ENST00000433060Q8IY63
ENSG00000166025ENST00000433060A0A024R3A6

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367510372023A mutational hotspot in AMOTL1 defines a new syndrome of orofacial clefting, cardiac anomalies, and tall stature.1
375586792023SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.0
367510372023A mutational hotspot in AMOTL1 defines a new syndrome of orofacial clefting, cardiac anomalies, and tall stature.1
375586792023SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1.0
330261502021De novo variant in AMOTL1 in infant with cleft lip and palate, imperforate anus and dysmorphic features.1
344807882021Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.6
330261502021De novo variant in AMOTL1 in infant with cleft lip and palate, imperforate anus and dysmorphic features.1
344807882021Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling.6
323132262020AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis.22
323132262020AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis.22
305318342019Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.90
307089592019Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases.12
305318342019Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.90
307089592019Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases.12
268063482016AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin.21

Citation

Dessen P

AMOTL1 (angiomotin like 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52612/amotl1-(angiomotin-like-1)