Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 154810
MIM: 614657
HGNC: 17811
Ensembl: ENSG00000166025
Variants:
dbSNP: 154810
ClinVar: 154810
TCGA: ENSG00000166025
COSMIC: AMOTL1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000166025 | ENST00000299004 | F8WDH4 |
| ENSG00000166025 | ENST00000317829 | Q8IY63 |
| ENSG00000166025 | ENST00000433060 | Q8IY63 |
| ENSG00000166025 | ENST00000433060 | A0A024R3A6 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Tight junction | KEGG | ko04530 |
| Tight junction | KEGG | hsa04530 |
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by Hippo | REACTOME | R-HSA-2028269 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36751037 | 2023 | A mutational hotspot in AMOTL1 defines a new syndrome of orofacial clefting, cardiac anomalies, and tall stature. | 1 |
| 37558679 | 2023 | SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1. | 0 |
| 36751037 | 2023 | A mutational hotspot in AMOTL1 defines a new syndrome of orofacial clefting, cardiac anomalies, and tall stature. | 1 |
| 37558679 | 2023 | SRSF3/AMOTL1 splicing axis promotes the tumorigenesis of nasopharyngeal carcinoma through regulating the nucleus translocation of YAP1. | 0 |
| 33026150 | 2021 | De novo variant in AMOTL1 in infant with cleft lip and palate, imperforate anus and dysmorphic features. | 1 |
| 34480788 | 2021 | Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling. | 6 |
| 33026150 | 2021 | De novo variant in AMOTL1 in infant with cleft lip and palate, imperforate anus and dysmorphic features. | 1 |
| 34480788 | 2021 | Angiomotin-like 1 plays a tumor-promoting role in glioma by enhancing the activation of YAP1 signaling. | 6 |
| 32313226 | 2020 | AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis. | 22 |
| 32313226 | 2020 | AMOTL1 enhances YAP1 stability and promotes YAP1-driven gastric oncogenesis. | 22 |
| 30531834 | 2019 | Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway. | 90 |
| 30708959 | 2019 | Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases. | 12 |
| 30531834 | 2019 | Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway. | 90 |
| 30708959 | 2019 | Angiomotin-Like 1 Links Paramyxovirus M Proteins to NEDD4 Family Ubiquitin Ligases. | 12 |
| 26806348 | 2016 | AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin. | 21 |
Citation
Dessen P
AMOTL1 (angiomotin like 1)
Atlas Genet Cytogenet Oncol Haematol. 2012-03-01
Online version: http://atlasgeneticsoncology.org/gene/52612/amotl1-(angiomotin-like-1)
