AMOTL1 (angiomotin like 1)

2012-03-01  

Identity

HGNC
LOCATION
11q21
LOCUSID
ALIAS
JEAP
FUSION GENES

Other Information

Locus ID:

NCBI: 154810
MIM: 614657
HGNC: 17811
Ensembl: ENSG00000166025

Variants:

dbSNP: 154810
ClinVar: 154810
TCGA: ENSG00000166025
COSMIC: AMOTL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166025ENST00000299004F8WDH4
ENSG00000166025ENST00000317829Q8IY63
ENSG00000166025ENST00000433060Q8IY63
ENSG00000166025ENST00000433060A0A024R3A6

Expression (GTEx)

0
10
20
30
40
50
60
70
80

Pathways

PathwaySourceExternal ID
Tight junctionKEGGko04530
Tight junctionKEGGhsa04530
Signal TransductionREACTOMER-HSA-162582
Signaling by HippoREACTOMER-HSA-2028269

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
253738972014Energy stress regulates hippo-YAP signaling involving AMPK-mediated regulation of angiomotin-like 1 protein.94
195900462009Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis.48
216859402012Opposing roles of angiomotin-like-1 and zona occludens-2 on pro-apoptotic function of YAP.48
252183442014MiR-124 represses vasculogenic mimicry and cell motility by targeting amotL1 in cervical cancer cells.35
243494732013Whole exome sequencing identifies novel recurrently mutated genes in patients with splenic marginal zone lymphoma.20
195656392009Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton.18
305318342019Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.15
199329122010PIV5 M protein interaction with host protein angiomotin-like 1.14
240032522013Angiomotin'g YAP into the nucleus for cell proliferation and cancer development.13
274980872016The endothelial E3 ligase HECW2 promotes endothelial cell junctions by increasing AMOTL1 protein stability via K63-linked ubiquitination.12

Citation

Dessen P

AMOTL1 (angiomotin like 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52612/amotl1-(angiomotin-like-1)