ADRA2C (adrenoceptor alpha 2C)

2012-03-01 Affiliation

Identity

HGNC

ADRA2C

LOCATION

4p16.3

LOCUSID

152

ALIAS

ADRA2L2,ADRA2RL2,ADRARL2,ALPHA2CAR

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 152
MIM: 104250
HGNC: 283
Ensembl: ENSG00000184160

Variants:

dbSNP: 152
ClinVar: 152
TCGA: ENSG00000184160
COSMIC: ADRA2C

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000184160	ENST00000330055	P18825
ENSG00000184160	ENST00000330055	Q4W594
ENSG00000184160	ENST00000509482	D6RGL0

Expression (GTEx)

100

150

200

250

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Metabolism of proteins	REACTOME	R-HSA-392499
Hemostasis	REACTOME	R-HSA-109582
Platelet activation, signaling and aggregation	REACTOME	R-HSA-76002
Platelet Aggregation (Plug Formation)	REACTOME	R-HSA-76009
Adrenaline signalling through Alpha-2 adrenergic receptor	REACTOME	R-HSA-392023
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Adrenoceptors	REACTOME	R-HSA-390696
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (z) signalling events	REACTOME	R-HSA-418597
Metabolism	REACTOME	R-HSA-1430728
Integration of energy metabolism	REACTOME	R-HSA-163685
Regulation of insulin secretion	REACTOME	R-HSA-422356
Adrenaline,noradrenaline inhibits insulin secretion	REACTOME	R-HSA-400042
Surfactant metabolism	REACTOME	R-HSA-5683826

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA165945764	bucindolol	Chemical	ClinicalAnnotation	associated	PD	23071495
PA444370	Heart Failure	Disease	ClinicalAnnotation	associated	PD	23071495
PA444797	Liver Cirrhosis	Disease	ClinicalAnnotation	associated	PD	20833658
PA448665	brimonidine	Chemical	Pathway	associated
PA449051	clonidine	Chemical	ClinicalAnnotation, Pathway	associated	PD	20833658
PA449396	dopamine	Chemical	Pathway	associated
PA449470	epinephrine	Chemical	Pathway	associated
PA450121	isoproterenol	Chemical	Pathway	associated
PA450649	norepinephrine	Chemical	Pathway	associated
PA451946	yohimbine	Chemical	Pathway	associated

References

Pubmed ID	Year	Title	Citations
35258481	2022	Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.	2
35258481	2022	Genetic biomarkers of life-threatening pheochromocytoma-induced cardiomyopathy.	2
34237656	2021	α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.	5
34237656	2021	α(2A)- and α(2C)-adrenoceptor expression and functionality in postmortem prefrontal cortex of schizophrenia subjects.	5
31218733	2019	Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.	20
31218733	2019	Prognostic significance of α- and β2-adrenoceptor gene expression in breast cancer patients.	20
29552726	2018	α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.	14
30273604	2018	Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction.	4
29552726	2018	α(2A)- and α(2C)-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.	14
30273604	2018	Human Placenta Expresses α(2)-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction.	4
26739946	2016	Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.	2
27007576	2016	Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence.	2
26739946	2016	Immunohistochemical localization of alpha and beta adrenergic receptors in the human nasal turbinate.	2
27007576	2016	Alpha2C-adrenoceptor Del322-325 polymorphism and risk of psychiatric disorders: significant association with opiate abuse and dependence.	2
25406899	2015	Adrenergic receptor genotype influences heart failure severity and β-blocker response in children with dilated cardiomyopathy.	3

Citation

Dessen P

ADRA2C (adrenoceptor alpha 2C)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52616/adra2c-(adrenoceptor-alpha-2c)