Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2731
MIM: 238300
HGNC: 4313
Ensembl: ENSG00000178445
Variants:
dbSNP: 2731
ClinVar: 2731
TCGA: ENSG00000178445
COSMIC: GLDC
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10074 | escitalopram | Chemical | ClinicalAnnotation | associated | PD | 21107318 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 21107318 | |
| PA449015 | citalopram | Chemical | ClinicalAnnotation | associated | PD | 21107318 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37668829 | 2023 | GLDC promotes colorectal cancer metastasis through epithelial-mesenchymal transition mediated by Hippo signaling pathway. | 1 |
| 37781511 | 2023 | Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer. | 0 |
| 37668829 | 2023 | GLDC promotes colorectal cancer metastasis through epithelial-mesenchymal transition mediated by Hippo signaling pathway. | 1 |
| 37781511 | 2023 | Glycine Decarboxylase (GLDC) Plays a Crucial Role in Regulating Energy Metabolism, Invasion, Metastasis and Immune Escape for Prostate Cancer. | 0 |
| 35460232 | 2022 | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. | 2 |
| 35460232 | 2022 | Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children. | 2 |
| 30498026 | 2019 | Identification and characterization of GLDC as host susceptibility gene to severe influenza. | 15 |
| 30779965 | 2019 | Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control. | 16 |
| 30804330 | 2019 | Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. | 22 |
| 31444411 | 2019 | Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity. | 19 |
| 31773974 | 2019 | Identification of a new GLDC gene alternative splicing variant and its protumorigenic roles in lung cancer. | 5 |
| 30498026 | 2019 | Identification and characterization of GLDC as host susceptibility gene to severe influenza. | 15 |
| 30779965 | 2019 | Glycine decarboxylase regulates the maintenance and induction of pluripotency via metabolic control. | 16 |
| 30804330 | 2019 | Glycine decarboxylase induces autophagy and is downregulated by miRNA-30d-5p in hepatocellular carcinoma. | 22 |
| 31444411 | 2019 | Glycine decarboxylase is a transcriptional target of MYCN required for neuroblastoma cell proliferation and tumorigenicity. | 19 |
Citation
Dessen P
GLDC (glycine decarboxylase)
Atlas Genet Cytogenet Oncol Haematol. 2012-03-01
Online version: http://atlasgeneticsoncology.org/gene/52629/gldc-(glycine-decarboxylase)
