P4HA2 (prolyl 4-hydroxylase subunit alpha 2)

2012-03-01  

Identity

HGNC
P4HA2
LOCATION
5q31.1
LOCUSID
8974
ALIAS
MYP25
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8974
MIM: 600608
HGNC: 8547
Ensembl: ENSG00000072682

Variants:

dbSNP: 8974
ClinVar: 8974
TCGA: ENSG00000072682
COSMIC: P4HA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000072682ENST00000166534O15460
ENSG00000072682ENST00000360568O15460
ENSG00000072682ENST00000379086O15460
ENSG00000072682ENST00000379100O15460
ENSG00000072682ENST00000379104O15460
ENSG00000072682ENST00000395164A8MXE0
ENSG00000072682ENST00000401867O15460
ENSG00000072682ENST00000416053C9JN43
ENSG00000072682ENST00000417528E7ENX0
ENSG00000072682ENST00000418055C9JIG4
ENSG00000072682ENST00000428369C9JCP0
ENSG00000072682ENST00000428841C9JFJ1
ENSG00000072682ENST00000431054E7EPI9
ENSG00000072682ENST00000439698E7ERI1
ENSG00000072682ENST00000453286C9JX45

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Arginine and proline metabolismKEGGhsa00330
Metabolic pathwaysKEGGhsa01100
Extracellular matrix organizationREACTOMER-HSA-1474244
Collagen formationREACTOMER-HSA-1474290
Collagen biosynthesis and modifying enzymesREACTOMER-HSA-1650814

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
387779982024P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway.0
389515932024P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma.0
387779982024P4HA2 contributes to head and neck squamous cell carcinoma progression and EMT through PI3K/AKT signaling pathway.0
389515932024P4HA2 promotes proliferation, invasion, and metastasis through regulation of the PI3K/AKT signaling pathway in oral squamous cell carcinoma.0
369062852023CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma.1
369433972023P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer.2
369062852023CEBPB upregulates P4HA2 to promote the malignant biological behavior in IDH1 wildtype glioma.1
369433972023P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer.2
356739092022[P4HA2 promotes occurrence and progression of liver cancer by regulating the PI3K/Akt/mTOR signaling pathway].2
364034272022High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis.1
356739092022[P4HA2 promotes occurrence and progression of liver cancer by regulating the PI3K/Akt/mTOR signaling pathway].2
364034272022High expression of prolyl 4-hydroxylase subunit alpha-2 in lung adenocarcinoma indicates poor prognosis.1
343871182021Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.3
344712352021P4HA2-induced prolyl hydroxylation suppresses YAP1-mediated prostate cancer cell migration, invasion, and metastasis.13
343871182021Prognostic and diagnostic roles of prolyl 4-hydroxylase subunit α members in breast cancer.3

Citation

Dessen P

P4HA2 (prolyl 4-hydroxylase subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52639/p4ha2-(prolyl-4-hydroxylase-subunit-alpha-2)