SLC7A6 (solute carrier family 7 member 6)

2012-03-01  

Identity

HGNC
LOCATION
16q22.1
LOCUSID
ALIAS
LAT-2,LAT3,y+LAT-2
FUSION GENES

Other Information

Locus ID:

NCBI: 9057
MIM: 605641
HGNC: 11064
Ensembl: ENSG00000103064

Variants:

dbSNP: 9057
ClinVar: 9057
TCGA: ENSG00000103064
COSMIC: SLC7A6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000103064ENST00000219343Q92536
ENSG00000103064ENST00000219343A0A024R719
ENSG00000103064ENST00000379152E7EPZ8
ENSG00000103064ENST00000562727H3BSV7
ENSG00000103064ENST00000563080H3BNF5
ENSG00000103064ENST00000563146H3BPV6
ENSG00000103064ENST00000564708H3BSB6
ENSG00000103064ENST00000566454Q92536
ENSG00000103064ENST00000566454A0A024R719
ENSG00000103064ENST00000566579H3BRZ8
ENSG00000103064ENST00000566834H3BUR2
ENSG00000103064ENST00000567346J3QL60
ENSG00000103064ENST00000568024H3BUA4
ENSG00000103064ENST00000568088H3BPK5
ENSG00000103064ENST00000618043E7EPZ8
ENSG00000103064ENST00000648130H3BNF5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Transmembrane transport of small moleculesREACTOMER-HSA-382551
SLC-mediated transmembrane transportREACTOMER-HSA-425407
Transport of inorganic cations/anions and amino acids/oligopeptidesREACTOMER-HSA-425393
Amino acid transport across the plasma membraneREACTOMER-HSA-352230

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
353147912022STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.7
353147912022STAT5A modulates CDYL2/SLC7A6 pathway to inhibit the proliferation and invasion of hepatocellular carcinoma by targeting to mTORC1.7
340507002021Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor.13
340507002021Functional analysis of LAT3 in prostate cancer: Its downstream target and relationship with androgen receptor.13
317056282020y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.19
317056282020y+LAT1 and y+LAT2 contribution to arginine uptake in different human cell models: Implications in the pathophysiology of Lysinuric Protein Intolerance.19
313452302019EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer.11
313452302019EGF-activated PI3K/Akt signalling coordinates leucine uptake by regulating LAT3 expression in prostate cancer.11
240526242013Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development.85
241427112013Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells.3
240526242013Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development.85
241427112013Suppression of amino acid transporter LAT3 expression on proliferation of K562 cells.3
232216992012The involvement of L-type amino acid transporters in theanine transport.2
232216992012The involvement of L-type amino acid transporters in theanine transport.2
220070002011Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.75

Citation

Dessen P

SLC7A6 (solute carrier family 7 member 6)

Atlas Genet Cytogenet Oncol Haematol. 2012-03-01

Online version: http://atlasgeneticsoncology.org/gene/52642/slc7a6-(solute-carrier-family-7-member-6)