ARNTL2 (aryl hydrocarbon receptor nuclear translocator like 2)

2012-04-01  

Identity

HGNC
ARNTL2
LOCATION
12p11.23
LOCUSID
56938
ALIAS
BMAL2,CLIF,MOP9,PASD9,bHLHe6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56938
MIM: 614517
HGNC: 18984
Ensembl: ENSG00000029153

Variants:

dbSNP: 56938
ClinVar: 56938
TCGA: ENSG00000029153
COSMIC: ARNTL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000029153ENST00000261178Q8WYA1
ENSG00000029153ENST00000266503Q8WYA1
ENSG00000029153ENST00000311001Q8WYA1
ENSG00000029153ENST00000395901Q8WYA1
ENSG00000029153ENST00000457040H0Y5R1
ENSG00000029153ENST00000542388Q8WYA1
ENSG00000029153ENST00000544915Q8WYA1
ENSG00000029153ENST00000546179Q8WYA1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Circadian ClockREACTOMER-HSA-400253
BMAL1:CLOCK,NPAS2 activates circadian gene expressionREACTOMER-HSA-1368108

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386608432024[Effects of BMAL2 on Aerobic Glycolysis and Cell Proliferation in Acute Myeloid Leukemia Cells].0
389385632024BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance.0
389560292024The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway.0
386608432024[Effects of BMAL2 on Aerobic Glycolysis and Cell Proliferation in Acute Myeloid Leukemia Cells].0
389385632024BMAL2 promotes eCIRP-induced macrophage endotoxin tolerance.0
389560292024The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway.0
328268562020ARNTL2 promotes pancreatic ductal adenocarcinoma progression through TGF/BETA pathway and is regulated by miR-26a-5p.22
328268562020ARNTL2 promotes pancreatic ductal adenocarcinoma progression through TGF/BETA pathway and is regulated by miR-26a-5p.22
271500382016An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency.63
271500382016An Arntl2-Driven Secretome Enables Lung Adenocarcinoma Metastatic Self-Sufficiency.63
264977752015Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.8
264977752015Association between brain-muscle-ARNT-like protein-2 (BMAL2) gene polymorphism and type 2 diabetes mellitus in obese Japanese individuals: A cross-sectional analysis of the Japan Multi-institutional Collaborative Cohort Study.8
246357572014Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures.15
248479622014The polymorphism of ARNTL2 (BMAL2) gene rs2306074 C>T is associated with susceptibility of Alzheimer disease in Chinese population.1
246357572014Polymorphisms in the circadian expressed genes PER3 and ARNTL2 are associated with diurnal preference and GNβ3 with sleep measures.15

Citation

Dessen P

ARNTL2 (aryl hydrocarbon receptor nuclear translocator like 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-04-01

Online version: http://atlasgeneticsoncology.org/gene/52688/arntl2-(aryl-hydrocarbon-receptor-nuclear-translocator-like-2)