Identity
HGNC
LOCATION
7p14.3
LOCUSID
ALIAS
CMT2D,DSMAV,GARS,GlyRS,HMN5,HMN5A,SMAD1,SMAJI
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2617
MIM: 600287
HGNC: 4162
Ensembl: ENSG00000106105
Variants:
dbSNP: 2617
ClinVar: 2617
TCGA: ENSG00000106105
COSMIC: GARS1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000106105 | ENST00000389266 | P41250 |
| ENSG00000106105 | ENST00000444666 | H7C443 |
| ENSG00000106105 | ENST00000454308 | F8WCK4 |
| ENSG00000106105 | ENST00000627489 | F8WCK4 |
Pathways
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37827278 | 2024 | Glycyl-tRNA Synthetase Induces Psoriasis-Like Skin by Facilitating Skin Inflammation and Vascular Endothelial Cell Angiogenesis. | 0 |
| 37827278 | 2024 | Glycyl-tRNA Synthetase Induces Psoriasis-Like Skin by Facilitating Skin Inflammation and Vascular Endothelial Cell Angiogenesis. | 0 |
| 36901698 | 2023 | Glycyl-tRNA Synthetase (GARS) Expression Is Associated with Prostate Cancer Progression and Its Inhibition Decreases Migration, and Invasion In Vitro. | 2 |
| 36901698 | 2023 | Glycyl-tRNA Synthetase (GARS) Expression Is Associated with Prostate Cancer Progression and Its Inhibition Decreases Migration, and Invasion In Vitro. | 2 |
| 35271987 | 2022 | GARS is implicated in poor survival and immune infiltration of hepatocellular carcinoma. | 8 |
| 35332613 | 2022 | Pathogenic missense variants altering codon 336 of GARS1 lead to divergent dominant phenotypes. | 2 |
| 35523311 | 2022 | Two distinct receptor-binding domains of human glycyl-tRNA synthetase 1 displayed on extracellular vesicles activate M1 polarization and phagocytic bridging of macrophages to cancer cells. | 3 |
| 35271987 | 2022 | GARS is implicated in poor survival and immune infiltration of hepatocellular carcinoma. | 8 |
| 35332613 | 2022 | Pathogenic missense variants altering codon 336 of GARS1 lead to divergent dominant phenotypes. | 2 |
| 35523311 | 2022 | Two distinct receptor-binding domains of human glycyl-tRNA synthetase 1 displayed on extracellular vesicles activate M1 polarization and phagocytic bridging of macrophages to cancer cells. | 3 |
| 33827397 | 2021 | Associations between Neurological Diseases and Mutations in the Human Glycyl-tRNA Synthetase. | 5 |
| 34403468 | 2021 | Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response. | 16 |
| 33827397 | 2021 | Associations between Neurological Diseases and Mutations in the Human Glycyl-tRNA Synthetase. | 5 |
| 34403468 | 2021 | Charcot-Marie-Tooth mutation in glycyl-tRNA synthetase stalls ribosomes in a pre-accommodation state and activates integrated stress response. | 16 |
| 31985473 | 2020 | Clinical and Genetic Features in a Series of Eight Unrelated Patients with Neuropathy Due to Glycyl-tRNA Synthetase (GARS) Variants. | 9 |
Citation
Dessen P
GARS1 (glycyl-tRNA synthetase 1)
Atlas Genet Cytogenet Oncol Haematol. 2012-05-01
Online version: http://atlasgeneticsoncology.org/gene/52713/gars1-(glycyl-trna-synthetase-1)
