LPCAT1 (lysophosphatidylcholine acyltransferase 1)

2012-05-01  

Identity

HGNC
LOCATION
5p15.33
LOCUSID
ALIAS
AGPAT10,AGPAT9,AYTL2,LPCAT-1,PFAAP3,lpcat,lysoPAFAT
FUSION GENES

Other Information

Locus ID:

NCBI: 79888
MIM: 610472
HGNC: 25718
Ensembl: ENSG00000153395

Variants:

dbSNP: 79888
ClinVar: 79888
TCGA: ENSG00000153395
COSMIC: LPCAT1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000153395ENST00000283415Q8NF37
ENSG00000153395ENST00000475622Q8NF37

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Ether lipid metabolismKEGGko00565
Glycerophospholipid metabolismKEGGhsa00564
Ether lipid metabolismKEGGhsa00565
Metabolic pathwaysKEGGhsa01100
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PAREACTOMER-HSA-1483166
Synthesis of PCREACTOMER-HSA-1483191
Acyl chain remodelling of PCREACTOMER-HSA-1482788
Acyl chain remodelling of PGREACTOMER-HSA-1482925
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
214985052011Human lysophosphatidylcholine acyltransferases 1 and 2 are located in lipid droplets where they catalyze the formation of phosphatidylcholine.53
204072082010LPCAT1 regulates surfactant phospholipid synthesis and is required for transitioning to air breathing in mice.45
181563672008Mammalian acyl-CoA:lysophosphatidylcholine acyltransferase enzymes.40
189749652009Lysophosphatidylcholine acyltransferase 1 (LPCAT1) overexpression in human colorectal cancer.38
235670802013Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression.30
221012582012The expression level of lysophosphatidylcholine acyltransferase 1 (LPCAT1) correlates to the progression of prostate cancer.25
257528902016Overexpression of Lysophosphatidylcholine Acyltransferase 1 and Concomitant Lipid Alterations in Gastric Cancer.24
256834842015Lysophosphatidylcholine acyltransferase 1 (LPCAT1) upregulation in breast carcinoma contributes to tumor progression and predicts early tumor recurrence.21
239417842013High lysophosphatidylcholine acyltransferase 1 expression independently predicts high risk for biochemical recurrence in prostate cancers.17
193839812009Biosynthesis of phosphatidylcholine by human lysophosphatidylcholine acyltransferase 1.13

Citation

Dessen P

LPCAT1 (lysophosphatidylcholine acyltransferase 1)

Atlas Genet Cytogenet Oncol Haematol. 2012-05-01

Online version: http://atlasgeneticsoncology.org/gene/52720/lpcat1-(lysophosphatidylcholine-acyltransferase-1)