HTR1A (5-hydroxytryptamine receptor 1A)

2012-06-01 Affiliation

Identity

HGNC

HTR1A

LOCATION

5q12.3

LOCUSID

3350

ALIAS

5-HT-1A,5-HT1A,5HT1a,ADRB2RL1,ADRBRL1,G-21,PFMCD

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3350
MIM: 109760
HGNC: 5286
Ensembl: ENSG00000178394

Variants:

dbSNP: 3350
ClinVar: 3350
TCGA: ENSG00000178394
COSMIC: HTR1A

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000178394	ENST00000323865	P08908
ENSG00000178394	ENST00000323865	Q5ZGX3
ENSG00000178394	ENST00000506598	D6RA34

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Taste transduction	KEGG	ko04742
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Taste transduction	KEGG	hsa04742
Serotonergic synapse	KEGG	hsa04726
cAMP signaling pathway	KEGG	hsa04024
cAMP signaling pathway	KEGG	ko04024
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280
Serotonin receptors	REACTOME	R-HSA-390666
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA162565877	amisulpride	Chemical	ClinicalAnnotation	associated	PD	22120873
PA164713257	Selective serotonin reuptake inhibitors	Chemical	ClinicalAnnotation, Literature, MultilinkAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030, 24930681
PA164752812	milnacipran	Chemical	ClinicalAnnotation	associated	PD	18484082
PA166129557	lurasidone	Chemical	ClinicalAnnotation	associated	PD	31636356
PA172	GNAI1	Gene	Pathway	associated		19741567
PA173	GNAI3	Gene	Pathway	associated		19741567
PA24347	GNAI2	Gene	Pathway	associated		19741567
PA446876	Substance-Related Disorders	Disease	ClinicalAnnotation	associated	PD	19747927
PA447207	Depressive Disorder	Disease	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA447212	Panic Disorder	Disease	ClinicalAnnotation	associated	PD	19590397, 19800133, 21688171
PA447216	Schizophrenia	Disease	ClinicalAnnotation	associated	PD	22120873, 25560469, 31636356
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	16302021, 18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA449061	clozapine	Chemical	ClinicalAnnotation	associated	PD	25560469
PA449673	fluoxetine	Chemical	ClinicalAnnotation	associated	PD	16302021, 19590397
PA449690	fluvoxamine	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA450403	methamphetamine	Chemical	ClinicalAnnotation	associated	PD	19747927
PA450688	olanzapine	Chemical	ClinicalAnnotation	associated	PD	22120873
PA450801	paroxetine	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA451201	quetiapine	Chemical	ClinicalAnnotation	associated	PD	22120873
PA451257	risperidone	Chemical	ClinicalAnnotation	associated	PD	22120873
PA451333	sertraline	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD	18047755, 18387740, 18484082, 19590397, 19800133, 21688171, 23733030
PA452233	antipsychotics	Chemical	ClinicalAnnotation	associated	PD	22120873

References

Pubmed ID	Year	Title	Citations
36214900	2023	Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis.	0
36533718	2023	Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin(1A) receptor.	1
36691786	2023	In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.	2
36769290	2023	Expression Patterns of Serotonin Receptors 5-HT1A, 5-HT2A, and 5-HT3A during Human Fetal Lung Development.	2
36980311	2023	HTR1A, TPH2, and 5-HTTLPR Polymorphisms and Their Impact on the Severity of Depressive Symptoms and on the Concentration of Tryptophan Catabolites during Hepatitis C Treatment with Pegylated Interferon-α2a and Oral Ribavirin (PEG-IFN-α2a/RBV).	0
37161455	2023	Influence of TPH2 and HTR1A polymorphisms on lifelong premature ejaculation risk among the chinese Han population.	0
37323077	2023	Association between single-nucleotide polymorphisms in serotonin receptor 2A and melatonin receptor 1A genes and pain after root canal treatment.	2
37473654	2023	The association between 5-HT1A binding and temporal lobe epilepsy: A meta-analysis of molecular imaging studies.	1
37525034	2023	ADRA2B and HTR1A: An Updated Study of the Biogenic Amine Receptors Reveals Novel Conserved Motifs Which Play Key Role in Mental Disorders.	2
37567783	2023	Gα Protein Signaling Bias at Serotonin 1A Receptor.	0
37958600	2023	Transcriptional Regulation of the Human 5-HT1A Receptor Gene by Lithium: Role of Deaf1 and GSK3β.	1
37984468	2023	Genetic variation of the 5-HT1A rs6295, 5-HT2A rs6311, and CNR1 rs1049353 and an altered endocannabinoid system in depressed patients.	1
36214900	2023	Association between the HTR1A rs6295 gene polymorphism and suicidal behavior: an updated meta-analysis.	0
36533718	2023	Metabolic depletion of sphingolipids inhibits agonist-induced endocytosis of the serotonin(1A) receptor.	1
36691786	2023	In vivo serotonin 1A receptor hippocampal binding potential in depression and reported childhood adversity.	2

Citation

Dessen P

HTR1A (5-hydroxytryptamine receptor 1A)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52726/htr1a-(5-hydroxytryptamine-receptor-1a)