NRXN3 (neurexin 3)

2012-06-01  

Identity

HGNC
NRXN3
LOCATION
14q31.1
LOCUSID
9369
ALIAS
C14orf60
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9369
MIM: 600567
HGNC: 8010
Ensembl: ENSG00000021645

Variants:

dbSNP: 9369
ClinVar: 9369
TCGA: ENSG00000021645
COSMIC: NRXN3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000021645ENST00000281127Q9HDB5
ENSG00000021645ENST00000335750A0A0A0MR89
ENSG00000021645ENST00000428277Q9HDB5
ENSG00000021645ENST00000553363H0YJL2
ENSG00000021645ENST00000553631G3V4R9
ENSG00000021645ENST00000554719Q9Y4C0
ENSG00000021645ENST00000554738Q9Y4C0
ENSG00000021645ENST00000555387A0A0C4DGK4
ENSG00000021645ENST00000557081G3V247
ENSG00000021645ENST00000557594Q9HDB5
ENSG00000021645ENST00000634499A0A0U1RQC5
ENSG00000021645ENST00000635466A0A0U1RRJ0

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
Neuronal SystemREACTOMER-HSA-112316
Protein-protein interactions at synapsesREACTOMER-HSA-6794362
Interactions of neurexins and neuroligins at synapsesREACTOMER-HSA-6794361

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil

References

Pubmed IDYearTitleCitations
340352172021Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.18
346472862021Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.0
347507902021Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.1
340352172021Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3.18
346472862021Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.0
347507902021Association of Nicotine Use Disorder with Neurexin 3 Gene Polymorphisms.1
309020612019Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.22
315782332019Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.8
309020612019Neurexin 3 transmembrane and soluble isoform expression and splicing haplotype are associated with neuron inflammasome and Alzheimer's disease.22
315782332019Modeling a Neurexin-3α Human Mutation in Mouse Neurons Identifies a Novel Role in the Regulation of Transsynaptic Signaling and Neurotransmitter Release at Excitatory Synapses.8
290450402018Neurexin gene family variants as risk factors for autism spectrum disorder.31
290450402018Neurexin gene family variants as risk factors for autism spectrum disorder.31
280132312017Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.24
280132312017Neurexins 1-3 Each Have a Distinct Pattern of Expression in the Early Developing Human Cerebral Cortex.24
244696092015Molecular analysis of cluster headache.15

Citation

Dessen P

NRXN3 (neurexin 3)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52734/nrxn3-(neurexin-3)