SRSF2 (serine and arginine rich splicing factor 2)

2012-06-01  

Identity

HGNC
SRSF2
LOCATION
17q25.1
LOCUSID
6427
ALIAS
PR264,SC-35,SC35,SFRS2,SFRS2A,SRp30b
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 6427
MIM: 600813
HGNC: 10783
Ensembl: ENSG00000161547

Variants:

dbSNP: 6427
ClinVar: 6427
TCGA: ENSG00000161547
COSMIC: SRSF2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161547ENST00000358156J3KP15
ENSG00000161547ENST00000359995Q01130
ENSG00000161547ENST00000359995A0A024R8U5
ENSG00000161547ENST00000392485Q01130
ENSG00000161547ENST00000392485A0A024R8U5
ENSG00000161547ENST00000452355Q01130
ENSG00000161547ENST00000452355A0A024R8U5
ENSG00000161547ENST00000508921Q01130
ENSG00000161547ENST00000583836J3QL05
ENSG00000161547ENST00000585202Q01130
ENSG00000161547ENST00000585202A0A024R8U5

Expression (GTEx)

0
50
100
150
200
250
300
350
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase II TranscriptionREACTOMER-HSA-73857
RNA Polymerase II Transcription TerminationREACTOMER-HSA-73856
Cleavage of Growing Transcript in the Termination RegionREACTOMER-HSA-109688
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
mRNA Splicing - Minor PathwayREACTOMER-HSA-72165
mRNA 3'-end processingREACTOMER-HSA-72187
Transport of Mature Transcript to CytoplasmREACTOMER-HSA-72202
Transport of Mature mRNA derived from an Intron-Containing TranscriptREACTOMER-HSA-159236

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386783222024[SRSF2 promotes glioblastoma cell proliferation by inducing alternative splicing of FSP1 and inhibiting ferroptosis].0
387135352024A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.1
386783222024[SRSF2 promotes glioblastoma cell proliferation by inducing alternative splicing of FSP1 and inhibiting ferroptosis].0
387135352024A mitochondrial surveillance mechanism activated by SRSF2 mutations in hematologic malignancies.1
373350452023Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3.0
373446412023Clinical and prognostic profile of SRSF2 and related spliceosome mutations in patients with acute myeloid leukemia.1
373548042023Co-occurring mutations in ASXL1, SRSF2, and SETBP1 define a subset of myelodysplastic/ myeloproliferative neoplasm with neutrophilia.0
378671922023SRSF2 is required for mRNA splicing during spermatogenesis.1
380650622023SRSF2 plays an unexpected role as reader of m(5)C on mRNA, linking epitranscriptomics to cancer.2
373350452023Serine-arginine splicing factor 2 promotes oesophageal cancer progression by regulating alternative splicing of interferon regulatory factor 3.0
373446412023Clinical and prognostic profile of SRSF2 and related spliceosome mutations in patients with acute myeloid leukemia.1
373548042023Co-occurring mutations in ASXL1, SRSF2, and SETBP1 define a subset of myelodysplastic/ myeloproliferative neoplasm with neutrophilia.0
378671922023SRSF2 is required for mRNA splicing during spermatogenesis.1
380650622023SRSF2 plays an unexpected role as reader of m(5)C on mRNA, linking epitranscriptomics to cancer.2
344649722022Genome-wide screening identifies cell-cycle control as a synthetic lethal pathway with SRSF2P95H mutation.6

Citation

Dessen P

SRSF2 (serine and arginine rich splicing factor 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-06-01

Online version: http://atlasgeneticsoncology.org/gene/52737/srsf2-(serine-and-arginine-rich-splicing-factor-2)