PHIP (pleckstrin homology domain interacting protein)

2012-08-01  

Identity

HGNC
PHIP
LOCATION
6q14.1
LOCUSID
55023
ALIAS
BRWD2,CHUJANS,DCAF14,DIDOD,WDR11,ndrp
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55023
MIM: 612870
HGNC: 15673
Ensembl: ENSG00000146247

Variants:

dbSNP: 55023
ClinVar: 55023
TCGA: ENSG00000146247
COSMIC: PHIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000146247ENST00000275034Q8WWQ0

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
334686472021Discovery of a hidden transient state in all bromodomain families.13
335034312021DCAF14 promotes stalled fork stability to maintain genome integrity.9
341717972021Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.3
348193532021A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.13
334686472021Discovery of a hidden transient state in all bromodomain families.13
335034312021DCAF14 promotes stalled fork stability to maintain genome integrity.9
341717972021Molecular double clips within RepID WD40 domain control chromatin binding and CRL4-substrate assembly.3
348193532021A trivalent nucleosome interaction by PHIP/BRWD2 is disrupted in neurodevelopmental disorders and cancer.13
319116552020The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.14
322733882020PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex.19
324923922020Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.25
319116552020The RepID-CRL4 ubiquitin ligase complex regulates metaphase to anaphase transition via BUB3 degradation.14
322733882020PHIP drives glioblastoma motility and invasion by regulating the focal adhesion complex.19
324923922020Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription.25
297769542018Role of Elevated PHIP Copy Number as a Prognostic and Progression Marker for Cutaneous Melanoma.10

Citation

Dessen P

PHIP (pleckstrin homology domain interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52801/phip-(pleckstrin-homology-domain-interacting-protein)