FEM1B (fem-1 homolog B)

2010-03-01  

Identity

HGNC
FEM1B
LOCATION
15q23
LOCUSID
10116
ALIAS
F1A-ALPHA,F1AA,FEM1-beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10116
MIM: 613539
HGNC: 3649
Ensembl: ENSG00000169018

Variants:

dbSNP: 10116
ClinVar: 10116
TCGA: ENSG00000169018
COSMIC: FEM1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169018ENST00000306917Q9UK73
ENSG00000169018ENST00000566008H3BT12
ENSG00000169018ENST00000566739H3BTV3

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383609922024Structural insights into the ubiquitylation strategy of the oligomeric CRL2(FEM1B) E3 ubiquitin ligase.0
383609922024Structural insights into the ubiquitylation strategy of the oligomeric CRL2(FEM1B) E3 ubiquitin ligase.0
333981682021Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.22
333981702021Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated recognition of C-degron.17
338924622021Structural insights into SMCR8 C-degron recognition by FEM1B.4
333981682021Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.22
333981702021Molecular basis for ubiquitin ligase CRL2(FEM1C)-mediated recognition of C-degron.17
338924622021Structural insights into SMCR8 C-degron recognition by FEM1B.4
281180782017FEM1 proteins are ancient regulators of SLBP degradation.18
281180782017FEM1 proteins are ancient regulators of SLBP degradation.18
240761222013Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.12
240761222013Fem1b promotes ubiquitylation and suppresses transcriptional activity of Gli1.12
199082422010Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells.12
202003322010Family-based analysis of candidate genes for polycystic ovary syndrome.47
199082422010Fem1b, a proapoptotic protein, mediates proteasome inhibitor-induced apoptosis of human colon cancer cells.12

Citation

Dessen P

FEM1B (fem-1 homolog B)

Atlas Genet Cytogenet Oncol Haematol. 2010-03-01

Online version: http://atlasgeneticsoncology.org/gene/52817/fem1b