THEMIS (thymocyte selection associated)

2012-08-01  

Identity

HGNC
LOCATION
6q22.33
LOCUSID
ALIAS
C6orf190,C6orf207,GASP,SPOT,TSEPA
FUSION GENES

Other Information

Locus ID:

NCBI: 387357
MIM: 613607
HGNC: 21569
Ensembl: ENSG00000172673

Variants:

dbSNP: 387357
ClinVar: 387357
TCGA: ENSG00000172673
COSMIC: THEMIS

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172673ENST00000368248Q8N1K5
ENSG00000172673ENST00000368250Q8N1K5
ENSG00000172673ENST00000434358X1WI26
ENSG00000172673ENST00000537166Q8N1K5
ENSG00000172673ENST00000626040A0A0D9SFD2
ENSG00000172673ENST00000630369Q8N1K5

Expression (GTEx)

0
1
2
3

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
282504242017THEMIS enhances TCR signaling and enables positive selection by selective inhibition of the phosphatase SHP-1.19
200958542010Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.16
227325882012Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.16
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
238204792014THEMIS and PTPRK in celiac intestinal mucosa: coexpression in disease and after in vitro gliadin challenge.11
195974982009Themis, a T cell-specific protein important for late thymocyte development.0
195974992009Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling.0
211892492011T cell receptor (TCR)-induced tyrosine phosphorylation dynamics identifies THEMIS as a new TCR signalosome component.0
226101192012Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer.0

Citation

Dessen P

THEMIS (thymocyte selection associated)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52829/themis-(thymocyte-selection-associated)