CNDP2 (carnosine dipeptidase 2)

2012-08-01  

Identity

HGNC
CNDP2
LOCATION
18q22.3
LOCUSID
55748
ALIAS
CN2,CPGL,HEL-S-13,HsT2298,PEPA
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55748
MIM: 169800
HGNC: 24437
Ensembl: ENSG00000133313

Variants:

dbSNP: 55748
ClinVar: 55748
TCGA: ENSG00000133313
COSMIC: CNDP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133313ENST00000324262Q96KP4
ENSG00000133313ENST00000324301Q96KP4
ENSG00000133313ENST00000577355A0A087WVS2
ENSG00000133313ENST00000577600J3QQN6
ENSG00000133313ENST00000579583J3QRA8
ENSG00000133313ENST00000579624J3KRJ8
ENSG00000133313ENST00000579847Q96KP4
ENSG00000133313ENST00000580672J3QRH4
ENSG00000133313ENST00000581272J3QRD0
ENSG00000133313ENST00000581513J3QLU1
ENSG00000133313ENST00000581912J3KSS4
ENSG00000133313ENST00000582260J3QRP4
ENSG00000133313ENST00000582589J3QKQ0
ENSG00000133313ENST00000582666J3KRD5
ENSG00000133313ENST00000583203J3QL02
ENSG00000133313ENST00000583216J3KSV5
ENSG00000133313ENST00000583785J3QKT2
ENSG00000133313ENST00000584613J3QR27
ENSG00000133313ENST00000584768A0A087WYZ1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Arginine and proline metabolismKEGGko00330
Histidine metabolismKEGGko00340
beta-Alanine metabolismKEGGko00410
Arginine and proline metabolismKEGGhsa00330
Histidine metabolismKEGGhsa00340
beta-Alanine metabolismKEGGhsa00410
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Sulfur amino acid metabolismREACTOMER-HSA-1614635
Biological oxidationsREACTOMER-HSA-211859
Phase II conjugationREACTOMER-HSA-156580
Glutathione conjugationREACTOMER-HSA-156590
Glutathione synthesis and recyclingREACTOMER-HSA-174403

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366377952023Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2).2
366377952023Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2).2
315371752019CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.5
315371752019CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.5
288718472017Single Nucleotide Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) are Associated With Power Athletic Status.6
290565062017The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form.3
294027792017The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.4
288718472017Single Nucleotide Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) are Associated With Power Athletic Status.6
290565062017The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form.3
294027792017The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.4
259643432015N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.36
259643432015N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.36
243955682014Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.14
248853952014Up-regulation of CNDP2 facilitates the proliferation of colon cancer.9
243955682014Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.14

Citation

Dessen P

CNDP2 (carnosine dipeptidase 2)

Atlas Genet Cytogenet Oncol Haematol. 2012-08-01

Online version: http://atlasgeneticsoncology.org/gene/52839/cndp2-(carnosine-dipeptidase-2)